Literature DB >> 44196

Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans.

S J Ashcroft, M R Christie.   

Abstract

The maximal extractable activity of "malic" enzyme (EC 1.1.1.40) in rat islets of Langerhans was similar to that reported for liver. Thus "malic" enzyme may catalyse a near-equilibrium reaction in the cytosol of islets of Langerhans. Measurements of islet content of malate and pyruvate, the metabolite substrate and product of "malic" enzyme, were therefore used to calculate the cytosolic ration of [NADPH]/[NADP+]. This ratio was higher in islets incubated with 20 mM-glucose than in islets incubated with 2 mM-glucose.

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Year:  1979        PMID： 44196      PMCID： PMC1161856          DOI： 10.1042/bj1840697

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  Subcellular distribution of key metabolites in isolated liver cells from fasted rats.

Authors:  E A Siess; D G Brocks; O H Wieland
Journal:  FEBS Lett       Date:  1976-10-15       Impact factor: 4.124

2.  Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats.

Authors:  M E Tischler; D Friedrichs; K Coll; J R Williamson
Journal:  Arch Biochem Biophys       Date:  1977-11       Impact factor: 4.013

3.  The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.

Authors:  A Sener; J C Hutton; S Kawazu; A C Boschero; G Somers; G Devis; A Herchuelz; W J Malaisse
Journal:  J Clin Invest       Date:  1978-10       Impact factor: 14.808

4.  The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.

Authors:  W J Malaisse; J C Hutton; S Kawazu; A Sener
Journal:  Eur J Biochem       Date:  1978-06-01

5.  The metabolism of glucose in pancreatic islets.

Authors:  A Sener; W J Malaisse
Journal:  Diabete Metab       Date:  1978-06

6.  Fructose and the dietary therapy of diabetes mellitus.

Authors:  L Sestoft
Journal:  Diabetologia       Date:  1979-07       Impact factor: 10.122

Review 7.  Insulin release: the fuel hypothesis.

Authors:  W J Malaisse; A Sener; A Herchuelz; J C Hutton
Journal:  Metabolism       Date:  1979-04       Impact factor: 8.694

8.  The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events.

Authors:  W J Malaisse; J C Hutton; S Kawazu; A Herchuelz; I Valverde; A Sener
Journal:  Diabetologia       Date:  1979-05       Impact factor: 10.122

9.  The stimulus-secretion coupling of glucose-induced insulin release. Cationic and secretory effects of menadione in the endocrine pancreas.

Authors:  W J Malaisse; A Sener; A C Boschero; S Kawazu; G Devis; G Somers
Journal:  Eur J Biochem       Date:  1978-06-01

10.  The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.

Authors:  A Sener; S Kawazu; J C Hutton; A C Boschero; G Devis; G Somers; A Herchuelz; W J Malaisse
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857
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  20 in total

Review 1.  Glucose-sensing mechanisms in pancreatic beta-cells.

Authors:  Patrick E MacDonald; Jamie W Joseph; Patrik Rorsman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-12-29       Impact factor: 6.237

2.  Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase.

Authors:  M Laclau; F Lu; M J MacDonald
Journal:  Mol Cell Biochem       Date:  2001-09       Impact factor: 3.396

Review 3.  Coupling factors in nutrient-induced insulin release.

Authors:  W J Malaisse; F Malaisse-Lagae; A Sener
Journal:  Experientia       Date:  1984-10-15

4.  Activation of oxoglutarate dehydrogenase in the kidney in response to acute acidosis.

Authors:  M Lowry; B D Ross
Journal:  Biochem J       Date:  1980-09-15       Impact factor: 3.857

Review 5.  Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets.

Authors:  P E MacDonald; M B Wheeler
Journal:  Diabetologia       Date:  2003-06-27       Impact factor: 10.122

6.  Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion.

Authors:  Thomas M Reinbothe; Rosita Ivarsson; Dai-Qing Li; Omid Niazi; Xingjun Jing; Enming Zhang; Lena Stenson; Ulrika Bryborn; Erik Renström
Journal:  Mol Endocrinol       Date:  2009-03-19

7.  The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state.

Authors:  A Sener; F Malaisse-Lagae; S P Dufrane; W J Malaisse
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

8.  Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT).

Authors:  V N Civelek; J T Deeney; K Kubik; V Schultz; K Tornheim; B E Corkey
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

9.  Cytosolic ratios of free [NADPH]/[NADP+] and [NADH]/[NAD+] in mouse pancreatic islets, and nutrient-induced insulin secretion.

Authors:  C J Hedeskov; K Capito; P Thams
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

10.  Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion.

Authors:  Rebecca L Pongratz; Richard G Kibbey; Gary W Cline
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600
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