Literature DB >> 6378186

The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state.

A Sener, F Malaisse-Lagae, S P Dufrane, W J Malaisse.   

Abstract

NADP-linked isocitrate dehydrogenase and malic enzyme [malate dehydrogenase (decarboxylating) (NADP)] activities were characterized in the cytosol of pancreatic islet cells. D-Glucose and L-leucine augmented the cytosolic NADPH/NADP+ ratio, as judged from the isocitrate/2-oxoglutarate and malate/pyruvate islet contents. The flow rate through the malic enzyme was judged from the output of labelled pyruvate by islets exposed to either L-[U-14C]glutamine or L-[U-14C]leucine. The cytosolic generation of NADPH, e.g. at the level of the malic enzyme, may play a role in the coupling of metabolic to secretory events in the process of nutrient-stimulated insulin release.

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Year:  1984        PMID： 6378186      PMCID： PMC1153644          DOI： 10.1042/bj2200433

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  30 in total

1.  The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.

Authors:  W J Malaisse; J C Hutton; S Kawazu; A Sener
Journal:  Eur J Biochem       Date:  1978-06-01

2.  The metabolism of glucose in pancreatic islets.

Authors:  A Sener; W J Malaisse
Journal:  Diabete Metab       Date:  1978-06

3.  The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal status.

Authors:  A L Greenbaum; K A Gumaa; P McLean
Journal:  Arch Biochem Biophys       Date:  1971-04       Impact factor: 4.013

4.  The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.

Authors:  W J Malaisse; G Brisson; F Malaisse-Lagae
Journal:  J Lab Clin Med       Date:  1970-12

5.  The stimulus-secretion coupling of glucose-induced insulin release. XXII. Qualitative and quantitative aspects of glycolysis in isolated islets.

Authors:  W J Malaisse; A Sener; J Levy; A Herchuelz
Journal:  Acta Diabetol Lat       Date:  1976 Sep-Dec

6.  Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin.

Authors:  H P Ammon; E Verspohl
Journal:  Endocrinology       Date:  1976-12       Impact factor: 4.736

7.  Mitochondrial and cytosolic NADPH systems and isocitrate dehydrogenase indicator metabolites during ureogensis from ammonia in isolated rat hepatocytes.

Authors:  H Sies; T P Akerboom; J M Tager
Journal:  Eur J Biochem       Date:  1977-01

8.  The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver.

Authors:  R L Veech; L V Eggleston; H A Krebs
Journal:  Biochem J       Date:  1969-12       Impact factor: 3.857

9.  Enzymes of glucose metabolism in normal mouse pancreatic islets.

Authors:  S J Ashcroft; P J Randle
Journal:  Biochem J       Date:  1970-08       Impact factor: 3.857

10.  The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.

Authors:  A Sener; S Kawazu; J C Hutton; A C Boschero; G Devis; G Somers; A Herchuelz; W J Malaisse
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857
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  17 in total

1.  Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase.

Authors:  M Laclau; F Lu; M J MacDonald
Journal:  Mol Cell Biochem       Date:  2001-09       Impact factor: 3.396

Review 2.  Coupling factors in nutrient-induced insulin release.

Authors:  W J Malaisse; F Malaisse-Lagae; A Sener
Journal:  Experientia       Date:  1984-10-15

Review 3.  Nutrient metabolism in islet cells.

Authors:  A Sener; W J Malaisse
Journal:  Experientia       Date:  1984-10-15

4.  Stimulation by D-glucose of mitochondrial oxidative events in islet cells.

Authors:  A Sener; W J Malaisse
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857

5.  Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

Authors:  Emma Heart; Gordon C Yaney; Richard F Corkey; Vera Schultz; Esthere Luc; Lihan Liu; Jude T Deeney; Orian Shirihai; Keith Tornheim; Peter J S Smith; Barbara E Corkey
Journal:  Biochem J       Date:  2007-04-01       Impact factor: 3.857

6.  Hexose metabolism in pancreatic islets: effect of D-glucose on the mitochondrial redox state.

Authors:  R Ramirez; A Sener; W J Malaisse
Journal:  Mol Cell Biochem       Date:  1995-01-12       Impact factor: 3.396

7.  Cytosolic ratios of free [NADPH]/[NADP+] and [NADH]/[NAD+] in mouse pancreatic islets, and nutrient-induced insulin secretion.

Authors:  C J Hedeskov; K Capito; P Thams
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

8.  Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.

Authors:  Changhong Li; Itzhak Nissim; Pan Chen; Carol Buettger; Habiba Najafi; Yevgeny Daikhin; Ilana Nissim; Heather W Collins; Marc Yudkoff; Charles A Stanley; Franz M Matschinsky
Journal:  J Biol Chem       Date:  2008-04-29       Impact factor: 5.157

9.  Fuel-induced amplification of insulin secretion in mouse pancreatic islets exposed to a high sulfonylurea concentration: role of the NADPH/NADP+ ratio.

Authors:  U Panten; I Rustenbeck
Journal:  Diabetologia       Date:  2007-10-25       Impact factor: 10.122

10.  Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

Authors:  Laura J Brown; Melissa J Longacre; Noaman M Hasan; Mindy A Kendrick; Scott W Stoker; Michael J Macdonald
Journal:  J Biol Chem       Date:  2009-12-18       Impact factor: 5.157
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