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Literature DB >> 441739

Periodicity of deoxyribonuclease I digestion of chromatin.

A Prunell, R D Kornberg, L Lutter, A Klug, M Levitt, F H Crick.

Abstract

Two methods have been used to measure the single-strand lengths of the DNA fragments produced by deoxyribonuclease I digestion of chromatin. The average lengths obtained are muliples of about 10.4 bases, significantly different from the value of 10 previously reported. This periodicity in fragment lengths is closely related to the periodicity of the DNA double helix in chromatin, but the two values need not be exactly the same.

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Year: 1979 PMID： 441739 DOI： 10.1126/science.441739

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

41 in total

1. DNase I digestion reveals alternating asymmetrical protection of the nucleosome by the higher order chromatin structure.

Authors: D Z Staynov
Journal: Nucleic Acids Res Date: 2000-08-15 Impact factor: 16.971

2. Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity.

Authors: Daisuke Shiokawa; Yukari Shika; Sei-ichi Tanuma
Journal: Biochem J Date: 2003-12-01 Impact factor: 3.857

Periodicity of deoxyribonuclease I digestion of chromatin.

1. DNase I digestion reveals alternating asymmetrical protection of the nucleosome by the higher order chromatin structure.

2. Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity.

3. Experimental evidence for asymmetrical shielding of nucleosomal DNA by histones.

4. The elastic rod model for DNA and its application to the tertiary structure of DNA minicircles in mononucleosomes.

5. A topological approach to nucleosome structure and dynamics: the linking number paradox and other issues.

6. UV-induced formation of pyrimidine dimers in nucleosome core DNA is strongly modulated with a period of 10.3 bases.

7. Organization of spacer DNA in chromatin.

8. Binding of cis- and trans-dichlorodiammineplatinum(II) to the nucleosome core.

9. Small DNA pieces in C. elegans are intermediates of DNA fragmentation during apoptosis.

10. Multiple phases of nucleosomes in the hsp 70 genes of Drosophila melanogaster.