Literature DB >> 4411728

A rapid, simple assay for digoxin.

H Greenwood, M Howard, J Landon.   

Abstract

An extremely rapid radioimmunoassay for digoxin is described which is precise over the range of concentrations required to determine whether, or not, a patient has digoxin toxicity. The assay is based on the use of (125)-iodine-labelled digoxin and of a gel equilibration technique for the separation of antibody-bound and free digoxin. The results obtained compare closely with those by a conventional radioimmunoassay and the technique is sufficiently simple to enable its performance by relatively inexperienced laboratory staff.

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Year:  1974        PMID: 4411728      PMCID: PMC478161          DOI: 10.1136/jcp.27.6.490

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN: 0021-9746            Impact factor:   3.411


  14 in total

1.  Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin.

Authors:  T W Smith; V P Butler; E Haber
Journal:  Biochemistry       Date:  1970-01-20       Impact factor: 3.162

2.  Digoxin-specific antibodies.

Authors:  V P Butler; J P Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1967-01       Impact factor: 11.205

3.  Improved radioimmunoassay of digoxin and other sterol-like compounds using Somogyi precipitation.

Authors:  R C Meade; T J Kleist
Journal:  J Lab Clin Med       Date:  1972-11

4.  Radioimmunoassay for digoxin. Technic and clinical application.

Authors:  G C Oliver; B M Parker; C W Parker
Journal:  Am J Med       Date:  1971-08       Impact factor: 4.965

5.  Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.

Authors:  T W Smith; V P Butler; E Haber
Journal:  N Engl J Med       Date:  1969-11-27       Impact factor: 91.245

6.  Plasma digoxin concentrations in patients with atrial fibrillation.

Authors:  D A Chamberlain; R J White; M R Howard; T W Smith
Journal:  Br Med J       Date:  1970-08-22

7.  Measurement of plasma digoxin concentration by radioimmunoassay.

Authors:  D C Evered; C Chapman; C J Hayter
Journal:  Br Med J       Date:  1970-08-22

8.  Coated charcoal immunoassay of insulin.

Authors:  V Herbert; K S Lau; C W Gottlieb; S J Bleicher
Journal:  J Clin Endocrinol Metab       Date:  1965-10       Impact factor: 5.958

9.  Steroid-protein interaction with particular reference to testosterone binding by human serum.

Authors:  W H Pearlman; O Crépy
Journal:  J Biol Chem       Date:  1967-01-25       Impact factor: 5.157

10.  Serum digoxin by radioimmunoassay.

Authors:  R J Hoeschen; V Proveda
Journal:  Can Med Assoc J       Date:  1971-07-24       Impact factor: 8.262

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  3 in total

1.  [A simplified radioimmunoassay for digoxin determination using a 125-j-labelled, solid-phase kit (author's transl)].

Authors:  W Doering; E Blümel
Journal:  Klin Wochenschr       Date:  1978-05-15

2.  Comparison of digoxin and medigoxin in normal subjects.

Authors:  R P Hayward; H Greenwood; J Hamer
Journal:  Br J Clin Pharmacol       Date:  1978-07       Impact factor: 4.335

3.  Relationship between myocardial uptake and actions in heart failure of methyldigoxin.

Authors:  R Hayward; H Greenwood; J Stephens; J Hamer
Journal:  Br J Clin Pharmacol       Date:  1983-01       Impact factor: 4.335

  3 in total

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