Literature DB >> 4405612

Characterization of the coronary vascular -adrenoceptor in the pig.

G M Drew, G P Levy.   

Abstract

The beta-adrenoceptor in pig coronary vascular smooth muscle has been characterized by the use of a selective agonist, salbutamol and a selective antagonist, practolol. In coronary artery strips contracted with KCI, salbutamol had only marginal relaxant activity and was a partial agonist compared with isoprenaline. Practolol had relatively high antagonist potency against isoprenaline (pA(2) 6.59). It is concluded that the pig coronary vascular,beta-adrenoceptor is of the beta(1)-type.

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Year:  1972        PMID： 4405612      PMCID： PMC1666354          DOI： 10.1111/j.1476-5381.1972.tb06880.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  20 in total

1.  Coronary and hemodynamic effects of myocardio-selective beta-receptor blockade by ICI 50172 in the closed-chest dog. Differentiation of coronary and myocardial beta receptors.

Authors:  W D Bussmann; M Rauh; H P Krayenbuehl
Journal:  Am Heart J       Date:  1970-03       Impact factor: 4.749

2.  Nutritional circulation in the heart. 3. Effect of isoproterenol and beta adrenergic blockade on myocardial hemodynamics and rubicium-86 extraction in the isolated supported heart preparation.

Authors:  P Somani; A R Laddu; H F Hardm
Journal:  J Pharmacol Exp Ther       Date:  1970-12       Impact factor: 4.030

3.  The action of practolol and propranolol on the rabbit isolated atrium.

Authors:  J Wale
Journal:  Eur J Pharmacol       Date:  1970-03       Impact factor: 4.432

4.  Effects of a cardio-selective beta-adrenergic blocking agent on the heart and coronary circulation.

Authors:  G Ross; C R Jorgensen
Journal:  Cardiovasc Res       Date:  1970-04       Impact factor: 10.787

5.  Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea.

Authors:  M Bristow; T R Sherrod; R D Green
Journal:  J Pharmacol Exp Ther       Date:  1970-01       Impact factor: 4.030

Review 6.  Pharmacological aspects of the coronary circulation.

Authors:  J R Parratt
Journal:  Prog Med Chem       Date:  1969

7.  Adrenergic receptors in coronary arteries.

Authors:  D F Bohr
Journal:  Ann N Y Acad Sci       Date:  1967-02-10       Impact factor: 5.691

8.  Differentiation of receptor systems activated by sympathomimetic amines.

Authors:  A M Lands; A Arnold; J P McAuliff; F P Luduena; T G Brown
Journal:  Nature       Date:  1967-05-06       Impact factor: 49.962

9.  Differentiation of receptors responsive to isoproterenol.

Authors:  A M Lands; F P Luduena; H J Buzzo
Journal:  Life Sci       Date:  1967-11-01       Impact factor: 5.037

10.  The effect of "selective" beta-adrenoceptor blocking drugs on the myocardial circulation.

Authors:  J R Parratt; R M Wadsworth
Journal:  Br J Pharmacol       Date:  1970-06       Impact factor: 8.739
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  7 in total

1.  Selectivity of beta-adrenoceptor agonists and antagonists on bronchial, skeletal, vascular and cardiac muscle in the anaesthetized cat.

Authors:  G H Apperley; M J Daly; G P Levy
Journal:  Br J Pharmacol       Date:  1976-06       Impact factor: 8.739

2.  In vitro activity of RO363, a beta1-adrenoceptor selective agonist.

Authors:  D Iakovidis; E Malta; G A McPherson; C Raper
Journal:  Br J Pharmacol       Date:  1980-04       Impact factor: 8.739

3.  The beta-adrenoceptor of pig coronary arteries: determination of beta 1 and beta 2 subtypes by radioligand binding.

Authors:  J Schwartz; J Velly
Journal:  Br J Pharmacol       Date:  1983-06       Impact factor: 8.739

4.  Effects of single doses of alprenolol and two cardioselective beta-blockers (H 87-07 and H 93-26) on exercise-induced angina pectoris.

Authors:  L Adolfsson; N H Areskog; C Furberg; G Johnsson
Journal:  Eur J Clin Pharmacol       Date:  1974       Impact factor: 2.953

5.  The release of a coronary vasodilator metabolite from the guinea-pig isolated perfused heart stimulated by catecholamines, histamine and electrical pacing and by exposure to anoxia.

Authors:  K J Broadley
Journal:  Br J Pharmacol       Date:  1976-09       Impact factor: 8.739

6.  Transient effects of norepinephrine on myocardial oxygen balance.

Authors:  W von Restorff; E Bassenge
Journal:  Pflugers Arch       Date:  1977-08-29       Impact factor: 3.657

7.  Effects of uptake inhibitors on responses of sheep coronary arteries to catecholamines and sympathetic nerve stimulation.

Authors:  F Brine; E J Cornish; R C Miller
Journal:  Br J Pharmacol       Date:  1979-12       Impact factor: 8.739
  7 in total

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