Literature DB >> 4404964

Conversion of allyl alcohol into acrolein by rat liver.

F Serafini-Cessi.   

Abstract

1. Acrolein was detected in rat liver suspensions incubated in the presence of allyl alcohol and allyl formate. Acrolein was determined by condensation of the distilled aldehyde with semicarbazide, followed by spectrophotometric measurement of the semicarbazone at 257nm and identification by paper chromatography. 2. The transformation of allyl alcohol into acrolein occurred in the presence of NAD(+). Inhibitors of rat liver alcohol dehydrogenase inhibited the reaction. 3. It is suggested that the hepatotoxic actions of allyl alcohol and of allyl formate on rat liver are related to their conversion into acrolein.

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Year:  1972        PMID： 4404964      PMCID： PMC1173998          DOI： 10.1042/bj1281103

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

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Review 7.  Carcinogenic nitroso compounds.

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9.  Rat liver alcohol dehydrogenase. Purification and properties.

Authors:  M J Arslanian; E Pascoe; J G Reinhold
Journal:  Biochem J       Date:  1971-12       Impact factor: 3.857
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  5 in total

1.  Identifying and designing chemicals with minimal acute aquatic toxicity.

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Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

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Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

5.  Ethnopharmacological based Evaluation of Anogeissus pendula Edgew Extracts for Antioxidant and Hepatoprotective Potential.

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  5 in total

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