Literature DB >> 439781

Indomethacin induced hypotension in sodium and volume depleted rats.

R Stahl, H Dienemann, U Kneissler, H Christ, U Helmchen.   

Abstract

After a single oral dose of 4 mg/kg indomethacin (IDM) to sodium and volume depleted rats plasma renin activity (PRA) and systolic blood pressure fell significantly within four hours. In sodium repleted animals indomethacin did not change systolic blood pressure (BP) although plasma renin activity was decreased. Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion.

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Year:  1979        PMID： 439781     DOI： 10.1007/bf01476055

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  21 in total

1.  Angiotensin. II. Important role in the maintenance of arterial blood pressure.

Authors:  J A Johnson; J O Davis
Journal:  Science       Date:  1973-03-02       Impact factor: 47.728

2.  The renin-angiotensin system and aldosterone secretion during sodium depletion in the rat.

Authors:  W S Spielman; J O Davis
Journal:  Circ Res       Date:  1974-10       Impact factor: 17.367

3.  Prostaglandin E2-9-ketoreductase as a mediator of salt intake-related prostaglandin-renin interaction.

Authors:  P C Weber; C Larsson; B Scherer
Journal:  Nature       Date:  1977-03-03       Impact factor: 49.962

4.  Letter: Arachidonic acid lowers and indomethacin increases the blood pressure of the rabbit.

Authors:  C Larsson; E Anggard
Journal:  J Pharm Pharmacol       Date:  1973-08       Impact factor: 3.765

5.  Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides.

Authors:  P C Webber; C Larsson; E Anggard; M Hamberg; E J Corey; K C Nicolaou; B Samuelsson
Journal:  Circ Res       Date:  1976-12       Impact factor: 17.367

6.  [The effect of indomethacin on basal and stimulated plasma renin activity in normal subjects (author's transl)].

Authors:  K W Rumpf; S Frenzel; H D Lowitz; F Scheler
Journal:  Klin Wochenschr       Date:  1976-03-15

7.  Angiotensin-sodium interaction in blood pressure maintenance of renal hypertensive and normotensive rats.

Authors:  H Gavras; H B Brunner; E D Vaughan; J H Laragh
Journal:  Science       Date:  1973-06-29       Impact factor: 47.728

8.  The role of the renin--angiotensin--aldosterone system in cardiovascular homeostasis in normal man.

Authors:  E Haber; J Sancho; R Re; J Burton; A C Barger
Journal:  Clin Sci Mol Med Suppl       Date:  1975-06

9.  Angiotensin II blockade in normal man: interaction of renin and sodium in maintaining blood pressure.

Authors:  L Posternak; H R Brunner; H Gavras; D B Brunner
Journal:  Kidney Int       Date:  1977-03       Impact factor: 10.612

10.  Role of prostaglandins in the control of renin secretion in the dog.

Authors:  J Yun; G Kelly; F C Bartter; H Smith
Journal:  Circ Res       Date:  1977-05       Impact factor: 17.367
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  1 in total

1.  Effect of indomethacin on blood pressure in rats with renovascular hypertension: dependence on plasma renin activity.

Authors:  R Stahl; H Dienemann; K Besserer; U Kneissler; U Helmchen
Journal:  Klin Wochenschr       Date:  1981-03-02
  1 in total

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