Literature DB >> 7012436

Effect of indomethacin on blood pressure in rats with renovascular hypertension: dependence on plasma renin activity.

R Stahl, H Dienemann, K Besserer, U Kneissler, U Helmchen.   

Abstract

The effect of the cyclooxygenase inhibitor indomethacin (3.4 mg/kg/24 hr) on systolic blood pressure (PB) and plasma-renin-activity (PRA) was evaluated in normotensive and renovascular hypertensive rats receiving either a normal or low salt diet. Indomethacin reduced PRA in normal and hypertensive animals on both low and normal salt intake. Indomethacin furthermore, decreased BP in animals on low sodium diet but increased PB in sodium repleted rats. These data suggest that the effect of indomethacin on rat BP may depend on the state of extracellular volume and PRA.

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Year:  1981        PMID： 7012436     DOI： 10.1007/bf01476582

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  14 in total

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Authors:  H G NOLLER
Journal:  Klin Wochenschr       Date:  1955-08-15

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Authors:  U Helmchen; U Kneissler
Journal:  Curr Top Pathol       Date:  1976

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Authors:  J W Aiken; J R Vane
Journal:  J Pharmacol Exp Ther       Date:  1973-03       Impact factor: 4.030

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Authors:  J A Johnson; J O Davis
Journal:  Science       Date:  1973-03-02       Impact factor: 47.728

5.  Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbit.

Authors:  C Larsson; P Weber; E Anggård
Journal:  Eur J Pharmacol       Date:  1974-10       Impact factor: 4.432

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Authors:  G Schaechtelin; D Regoli; G Peters
Journal:  Helv Physiol Pharmacol Acta       Date:  1967

7.  Increase of experimental hypertension following inhibition of prostaglandin biosynthesis.

Authors:  B A Schölkens; R Steinbach
Journal:  Arch Int Pharmacodyn Ther       Date:  1975-04

8.  Renal functional and organic changes induced by salt and prostaglandin inhibition in spontaneously hypertensive rats.

Authors:  S G Chrysant; A K Mandal; J A Nordquist
Journal:  Nephron       Date:  1980       Impact factor: 2.847

9.  Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs.

Authors:  J M De Forrest; J O Davis; R H Freeman; A A Seymour; B P Rowe; G M Williams; T P Davis
Journal:  Circ Res       Date:  1980-07       Impact factor: 17.367

10.  Renal hypotension in sodium and fluid deprivation: experimental findings in renin-depleted rats.

Authors:  U Helmchen; H Dienemann; U Kneissler; R Stahl; E J Kirchertz
Journal:  Klin Wochenschr       Date:  1978-03-01
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  1 in total

1.  Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner.

Authors:  Morag K Mansley; Christian Niklas; Regina Nacken; Kathrin Mandery; Hartmut Glaeser; Martin F Fromm; Christoph Korbmacher; Marko Bertog
Journal:  J Gen Physiol       Date:  2020-08-03       Impact factor: 4.086
  1 in total

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