Literature DB >> 4388010

Studies in the enzymology of glutathione metabolism in human erythrocytes.

R C Jackson.   

Abstract

Spectrophotometric assay methods are described for glutathione synthetase, gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase of erythrocytes. The contents of these enzymes in normal human erythrocytes are reported. Erythrocyte glutathione synthetase is inhibited by ADP; this inhibition is competitive with respect to ATP. gamma-Glutamylcysteine synthetase is subject to feedback inhibition by GSH, and is also inhibited by NADH, and to a lesser extent by NAD(+) and NADPH. This enzyme is irreversibly inactivated by cysteamine.

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Year:  1969        PMID： 4388010      PMCID： PMC1187513          DOI： 10.1042/bj1110309

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Studies on normal and leukemic leukocytes. III. Pyridine nucleotides.

Authors:  R SILBER; B W GABRIO; F M HUENNEKENS
Journal:  J Clin Invest       Date:  1962-02       Impact factor: 14.808

2.  The reduction of disulphides by human erythrocytes.

Authors:  L ELDJARN; J BREMER; H C BORRESEN
Journal:  Biochem J       Date:  1962-01       Impact factor: 3.857

3.  Acidic peptides of the lens. 6. Metabolism of gamma-glutamyl peptides in subcellular fractions of rabbit liver.

Authors:  E E CLIFFE; S G WALEY
Journal:  Biochem J       Date:  1961-04       Impact factor: 3.857

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Authors:  J W PATTERSON; A LAZAROW
Journal:  Methods Biochem Anal       Date:  1955

5.  Biosynthesis of glutathione by rat erythrocytes.

Authors:  D K KASBEKAR; A SREENIVASAN
Journal:  Biochem J       Date:  1959-07       Impact factor: 3.857

6.  Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown.

Authors:  G C MILLS
Journal:  J Biol Chem       Date:  1957-11       Impact factor: 5.157

7.  Effects of sulfhydryl inhibition on red blood cells. 3. Glutathione in the regulation of the hexose monophosphate pathway.

Authors:  H S Jacob; J H Jandl
Journal:  J Biol Chem       Date:  1966-09-25       Impact factor: 5.157

8.  Cysteamine-induced increase of cellular glutathione-level: a new hypothesis of the radioprotective mechanism.

Authors:  L Révész; H Modig
Journal:  Nature       Date:  1965-07-24       Impact factor: 49.962

9.  [Glutathione synthesis during congenital hemolytic anemia with reduced glutathione deficiency. Congenital erythrocytic glutathione-synthetase deficiency?].

Authors:  P Boivin; C Galand
Journal:  Nouv Rev Fr Hematol       Date:  1965 Sep-Oct

10.  SOME BIOCHEMICAL ASPECTS OF LEUKAEMIAS: THE APPEARANCE OF A SOLUBLE DISULPHIDE IN THE BLOOD IN CHRONIC GRANULOCYTIC LEUKAEMIA.

Authors:  K R HARRAP; D E SPEED
Journal:  Br J Cancer       Date:  1964-12       Impact factor: 7.640
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  9 in total

1.  Mechanisms of gamma-glutamylcysteine ligase regulation.

Authors:  Dikran Toroser; Connie S Yarian; William C Orr; Rajindar S Sohal
Journal:  Biochim Biophys Acta       Date:  2005-11-17

2.  λ-Glutamylcysteine synthetase in higher plants: catalytic properties and subcellular localization.

Authors:  R Hell; L Bergmann
Journal:  Planta       Date:  1990-03       Impact factor: 4.116

Review 3.  [Glutathione peroxidase: enzymology and biological aspects].

Authors:  L Flohé
Journal:  Klin Wochenschr       Date:  1971-06-15

4.  Some effects of chlorambucil on enzymes of glutathione metabolism in drug-sensitive and -resistant strains of the Yoshida ascites sarcoma.

Authors:  K R Harrap; R C Jackson; B T Hill
Journal:  Biochem J       Date:  1969-02       Impact factor: 3.857

5.  Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data.

Authors:  Julia E Raftos; Stephney Whillier; Philip W Kuchel
Journal:  J Biol Chem       Date:  2010-05-24       Impact factor: 5.157

6.  Assay, purification, properties and mechanism of action of gamma-glutamylcysteine synthetase from the liver of the rat and Xenopus laevis.

Authors:  J S Davis; J B Balinsky; J S Harington; J B Shepherd
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

7.  Formation of 5-oxoproline from glutathione in erythrocytes by the gamma-glutamyltranspeptidase-cyclotransferase pathway.

Authors:  A G Palekar; S S Tate; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205

8.  Effect of Methylene Blue on glutamate and reduced glutathione of rabbit erythrocytes.

Authors:  J E Smith; E Mahaffey; M Lee
Journal:  Biochem J       Date:  1977-12-15       Impact factor: 3.857

9.  Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates.

Authors:  V Minnich; M B Smith; M J Brauner; P W Majerus
Journal:  J Clin Invest       Date:  1971-03       Impact factor: 14.808
  9 in total

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