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Literature DB >> 1260223

Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate.

M O Carruba, A Groppetti, P Mantegazza, L Vicentini, F Zambotti.

Abstract

1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1976 PMID： 1260223 PMCID： PMC1666899 DOI： 10.1111/j.1476-5381.1976.tb07454.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

27 in total

1. [Anorexigenic phenylalkylamines and serotonin metabolism].

Authors: K Opitz
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1967

2. Is 5-hydroxytryptamine involved in the mechanism of action of fenfluramine?

Authors: W H Funderburk; J C Hazelwood; R T Ruckart; J W Ward
Journal: J Pharm Pharmacol Date: 1971-06 Impact factor: 3.765

3. On the effect of anorectic drugs on striatum homovanillic acid in rats.

Authors: A Jori; E Dolfini
Journal: Pharmacol Res Commun Date: 1974-04

4. The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine.

Authors: R Samanin; D Ghezzi; L Valzelli; S Garattini
Journal: Eur J Pharmacol Date: 1972-09 Impact factor: 4.432

5. A simple procedure for calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.

Authors: N H Neff; P F Spano; A Groppetti; C T Wang; E Costa
Journal: J Pharmacol Exp Ther Date: 1971-03 Impact factor: 4.030

6. The role of brain serotonin in the mechanism of the central action of reserpine.

Authors: B B Brodie; M S Comer; E Costa; A Dlabac
Journal: J Pharmacol Exp Ther Date: 1966-05 Impact factor: 4.030

7. [Modification of the cerebral serotonin level in the rat by trifluoromethyl-2-phenyl ethyl aminopropane (Fenfluramine 768 S)].

Authors: J Duhault; C Verdavainne
Journal: Arch Int Pharmacodyn Ther Date: 1967-12

8. Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.

Authors: N E Andén; S G Butcher; H Corrodi; K Fuxe; U Ungerstedt
Journal: Eur J Pharmacol Date: 1970 Impact factor: 4.432

9. The effects of 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo (2, 1-a) isoindole (mazindol, SaH 42-548) on the metabolism of brain norepinephrine.

Authors: R G Engstrom; L A Kelly; J H Gogerty
Journal: Arch Int Pharmacodyn Ther Date: 1975-04

6. Effects of mazindol, fenfluramine and chlorimipramine on the 5-hydroxytryptamine uptake and storage mechanisms in rat brain: similarities and differences.

Authors: M O Carruba; G B Picotti; F Zambotti; P Mantegazza
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-11 Impact factor: 3.000

6 in total

Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate.

1. [Anorexigenic phenylalkylamines and serotonin metabolism].

2. Is 5-hydroxytryptamine involved in the mechanism of action of fenfluramine?

3. On the effect of anorectic drugs on striatum homovanillic acid in rats.

4. The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine.

5. A simple procedure for calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.

6. The role of brain serotonin in the mechanism of the central action of reserpine.

7. [Modification of the cerebral serotonin level in the rat by trifluoromethyl-2-phenyl ethyl aminopropane (Fenfluramine 768 S)].

8. Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.

9. The effects of 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo (2, 1-a) isoindole (mazindol, SaH 42-548) on the metabolism of brain norepinephrine.

10. Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia.

1. Mazindol and amphetamine as inhibitors of the uptake and releasers of 3H-dopamine by rat striatal synaptosomes.

2. The anorectic action of mazindol.

3. Inhibition of foot intake in the rat.

4. Mazindol anorexia is mediated by activation of dopaminergic mechanisms.

5. Effect of mazindol on brain dopamine turnover in spiperone-treated rats.

6. Effects of mazindol, fenfluramine and chlorimipramine on the 5-hydroxytryptamine uptake and storage mechanisms in rat brain: similarities and differences.