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Literature DB >> 4372628

Collagenase production by endotoxin-activated macrophages.

L M Wahl, S M Wahl, S E Mergenhagen, G R Martin.

Abstract

Peritoneal exudate macrophages, when exposed to bacterial lipopolysaccharide in culture, were found to produce collagenase (EC 3.4.24.3). This enzyme was not detected in extracts of the macrophages or in media from nonstimulated macrophage cultures. Lipidcontaining fractions of the lipopolysaccharide, including a glycolipid from the rough mutant of Salmonella minnesota (R595) and lipid A, were potent stimulators of collagenase production. The lipid-free polysaccharide fraction had no effect. Cycloheximide prevented the production of collagenase by endotoxin-treated macrophages, suggesting that it was newly synthesized.

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Year: 1974 PMID： 4372628 PMCID： PMC433822 DOI： 10.1073/pnas.71.9.3598

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Effect of lymphocyte mediators on macrophages in vitro. A correlation of morphological and cytochemical changes.

Authors: I Nath; L W Poulter; J L Turk
Journal: Clin Exp Immunol Date: 1973-03 Impact factor: 4.330

2. Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis.

Authors: H Furthmayr; R Timpl
Journal: Anal Biochem Date: 1971-06 Impact factor: 3.365

3. Collagenase from rat uterus. Isolation and partial characterization.

Authors: J J Jeffrey; J Gross
Journal: Biochemistry Date: 1970-01-20 Impact factor: 3.162

4. Degradation of collagen by a human granulocyte collagenolytic system.

Authors: G S Lazarus; J R Daniels; R S Brown; H A Bladen; H M Fullmer
Journal: J Clin Invest Date: 1968-12 Impact factor: 14.808

5. Tadpole collagenase. Preparation and purification.

Authors: Y Nagai; C M Lapiere; J Gross
Journal: Biochemistry Date: 1966-10 Impact factor: 3.162

6. Human skin collagenase. Isolation and mechanism of attack on the collagen molecule.

Authors: A Z Eisen; J J Jeffrey; J Gross
Journal: Biochim Biophys Acta Date: 1968-03-25

7. Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T 6 T 6 thymus grafts.

Authors: I Gery; J Krüger; S Z Spiesel
Journal: J Immunol Date: 1972-04 Impact factor: 5.422

8. Metabolic and morphological observations on the effect of surface-active agents of leukocytes.

Authors: R C Graham; M J Karnovsky; A W Shafer; E A Glass; M L Karnovsky
Journal: J Cell Biol Date: 1967-03 Impact factor: 10.539

9. Relation of structure to function in bacterial O antigens. II. Fractionation of lipids present in Boivin-type endotoxin of Serratia marcescens.

Authors: A NOWOTNY
Journal: J Bacteriol Date: 1963-02 Impact factor: 3.490

10. Alterations of macrophage functions by mediators from lymphocytes.

Authors: C F Nathan; M L Karnovsky; J R David
Journal: J Exp Med Date: 1971-06-01 Impact factor: 14.307

71 in total

1. Synthesis of factors D, B and P of the alternative pathway of complement activation, as well as of C3, by guinea-pig peritoneal macrophages in vitro.

Authors: C Bentley; W Fries; V Brade
Journal: Immunology Date: 1978-12 Impact factor: 7.397

2. What makes silica toxic?

Authors: N Bagchi
Journal: Br J Ind Med Date: 1992-03

Review 3. Lysosomal enzymes of phagocytes and the mechanism of their release.

Authors: M Ferencík; J Stefanovic
Journal: Folia Microbiol (Praha) Date: 1979 Impact factor: 2.099

Review 4. The role of the macrophage in collagen resorption during chronic inflammation. A new look at an old hypothesis.

Authors: D A Deporter
Journal: Agents Actions Date: 1979-06