Literature DB >> 436447

Gene dosage effect: intraband mapping of human soluble glutamic oxaloacetic transaminase.

R A Spritz, B S Emanuel, C J Chern, W J Mellman.   

Abstract

Quantitative assays of soluble GOT were performed on fibroblasts (from two individuals) with duplications of the long arm of chromosome 10 (10q24 leads to qter). Improved karyologic technique demonstrated that the duplications differ by half a band. Correlation of GOTS activity with the karyologic data indicates that the structural locus for GOTS maps within band 10q24. This study demonstrates the utility of this approach to fine structural mapping of the human genome.

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Year:  1979        PMID： 436447     DOI： 10.1159/000131320

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  4 in total

1.  Chromosomal localization of the human elastin gene.

Authors:  B S Emanuel; L Cannizzaro; N Ornstein-Goldstein; Z K Indik; K Yoon; M May; L Oliver; C Boyd; J Rosenbloom
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025

2.  Confirmation of a de novo duplication, dup(10)(q24 leads to q26), by GOT1 gene dosage studies.

Authors:  D J Tomkins; B J Gitelman; M H Roberts
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

3.  Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization.

Authors:  S Pol; B Bousquet-Lemercier; M Pavé-Preux; F Bulle; E Passage; J Hanoune; M G Mattei; R Barouki
Journal:  Hum Genet       Date:  1989-09       Impact factor: 4.132

4.  Suggested assignment of peptidase S (PEPS) to 4p11-4q12 by exclusion using gene dosage, accounting for variability in fibroblasts.

Authors:  S M Schmutz; N E Simpson
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132
  4 in total

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