Literature DB >> 2777255

Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization.

S Pol1, B Bousquet-Lemercier, M Pavé-Preux, F Bulle, E Passage, J Hanoune, M G Mattei, R Barouki.   

Abstract

The localization of the human genes for cytosolic and mitochondrial aspartate aminotransferase (AspAT) has been determined by chromosomal in situ hybridization with specific human cDNA probes previously characterized in our laboratory. The cytosolic AspAT gene is localized on chromosome 10 at the interface of bands q241-q251. Mitochondrial AspAT is characterized by a multigene family located on chromosomes 12 (p131-p132), 16 (q21), and 1 (p32-p33 and q25-q31). Genomic DNA from ten blood donors was digested by ten restriction enzymes, and Southern blots were hybridized with the two specific probes. Restriction fragment length polymorphism was revealed in only one case for cytosolic AspAT, with PvuII, while no polymorphism for mitochondrial AspAT was found.

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Year:  1989        PMID： 2777255     DOI： 10.1007/BF00286710

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  21 in total

1.  Assignment of a gene necessary for the expression of mitochondrial glutamic-oxaloacetic transaminase in human-mouse hybrid cells.

Authors:  I W Craig; E Tolley; M Bobrow; V van Heyningen
Journal:  Cytogenet Cell Genet       Date:  1978

2.  Increase in mitochondrial GOT (m-GOT) activity after chronic alcohol consumption: clinical and experimental observations.

Authors:  F Okuno; H Ishii; K Kashiwazaki; S Takagi; Y Shigeta; M Arai; T Takagi; Y Ebihara; M Tsuchiya
Journal:  Alcohol       Date:  1988 Jan-Feb       Impact factor: 2.405

3.  Structural organization of the mouse mitochondrial aspartate aminotransferase gene.

Authors:  T Tsuzuki; K Obaru; C Setoyama; K Shimada
Journal:  J Mol Biol       Date:  1987-11-05       Impact factor: 5.469

4.  Nucleotide sequence and glucocorticoid regulation of the mRNAs for the isoenzymes of rat aspartate aminotransferase.

Authors:  M Pavé-Preux; N Ferry; J Bouguet; J Hanoune; R Barouki
Journal:  J Biol Chem       Date:  1988-11-25       Impact factor: 5.157

5.  Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA.

Authors:  S Pol; B Bousquet-Lemercier; M Pave-Preux; A Pawlak; B Nalpas; P Berthelot; J Hanoune; R Barouki
Journal:  Biochem Biophys Res Commun       Date:  1988-12-30       Impact factor: 3.575

6.  Genetic polymorphisms of human mitochondrial glutamic oxaloacetic transaminase.

Authors:  R G Davidson; J A Cortner; M C Rattazzi; F H Ruddle; H A Lubs
Journal:  Science       Date:  1970-07-24       Impact factor: 47.728

7.  Gene dosage evidence for the regional assignment of the GOTS structural gene locus to 10q24 leads to 10q25.

Authors:  D A Aitken; M A Ferguson-Smith
Journal:  Cytogenet Cell Genet       Date:  1978

8.  Biosynthesis of aspartate aminotransferases. Both the higher molecular weight precursor of mitochondrial aspartate aminotransferase and the cytosolic isoenzyme are synthesized on free polysomes.

Authors:  P Sonderegger; R Jaussi; P Christen; H Gehring
Journal:  J Biol Chem       Date:  1982-03-25       Impact factor: 5.157

9.  Mapping studies on human mitochondrial glutamate oxaloacetate transaminase.

Authors:  S J Jeremiah; S Povey; M W Burley; C Kielty; M Lee; G Spowart; G Corney; P J Cook
Journal:  Ann Hum Genet       Date:  1982-05       Impact factor: 1.670

10.  Human mitochondrial glutamic-oxaloacetic-transaminase, GOTM: formal genetics.

Authors:  H Ritter; J Kömpf
Journal:  Hum Genet       Date:  1979-10-02       Impact factor: 4.132
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  1 in total

Review 1.  The past and present of serum aminotransferases and the future of liver injury biomarkers.

Authors:  Mitchell R McGill
Journal:  EXCLI J       Date:  2016-12-15       Impact factor: 4.068
  1 in total

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