Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Relationships between the haemolytic activities of the human complement system and complement components.

Literature DB >> 436337

Relationships between the haemolytic activities of the human complement system and complement components.

Abstract

The relationships between the haemolytic activities of complement and its components were studied. The activities studied included CH50 (classical pathway), AP50 (alternative pathway), CV50 (early part of alternative pathway) and C(3--9)H50 ((the late part of both pathways). The components included C3, C4, C5, C9, B and D. There was a good correlation between CH50 and AP50. AP50 had a good correlation with B and CV50. There was no correlation between AP50 and C(3--9)H50, and none between C(3--9)H50 and C5 or C9. AP50 may primarily represent changes in the early part of the alternative pathway. C(3--9)H50 is not influenced by respective changes in the amounts of C5 or C9. Since cell lesion is now considered to be caused by a unit of C5b to C9, a change in each component of C5 to C9 may not influence haemolytic activity.

Entities: Gene Species

Mesh：

Substances：

Year: 1979 PMID： 436337 PMCID： PMC1537652

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

12 in total

1. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.

Authors: L PILLEMER; L BLUM; I H LEPOW; O A ROSS; E W TODD; A C WARDLAW
Journal: Science Date: 1954-08-20 Impact factor: 47.728

2. Activation of the alternate pathway of human complements by rabbit cells.

Authors: T A Platts-Mills; K Ishizaka
Journal: J Immunol Date: 1974-07 Impact factor: 5.422

3. Isolation of the anticomplementary protein from cobra venom and its mode of action on C3.

Authors: H J Müller-Eberhard; K E Fjellström
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

4. Effect of tranexamic acid, t-AMCHA, and its cis-isomer on the complement system in vitro and in vivo: possible relationship between coagulation and complement systems.

Authors: A Takada; Y Takada
Journal: Thromb Res Date: 1978-08 Impact factor: 3.944

5. Inhibition of the classical and alternative pathways by amino acids and their derivatives.

Authors: Y Takada; Y Arimoto; H Mineda; A Takada
Journal: Immunology Date: 1978-03 Impact factor: 7.397

6. Haemolytic diffusion plate assays for factors B and D of the alternative pathway of complement activation.

Authors: A Martin; P J Lachmann; L Halbwachs; M J Hobart
Journal: Immunochemistry Date: 1976-04

7. Presidential address to the American Association of Immunologists, delivered in Chicago, Illinois, April 6, 1977. Mechanism of cytolysis by lymphocytes: A comparison with complement.

Authors: M M Mayer
Journal: J Immunol Date: 1977-10 Impact factor: 5.422

8. Studies of the C3 shunt activation in cobra venom induced lysis of unsensitized erythrocytes.

Authors: M Brai; A G Osler
Journal: Proc Soc Exp Biol Med Date: 1972-07

9. Two anticomplementary factors in cobra venom: hemolysis of guinea pig erythrocytes by one of them.

Authors: M Ballow; C G Cochrane
Journal: J Immunol Date: 1969-11 Impact factor: 5.422

10. Enharncement of the hemolytic activity of the second component of human complement by oxidation.

Authors: M J Polley; H J Müller-Eberhard
Journal: J Exp Med Date: 1967-12-01 Impact factor: 14.307

4 in total

1. Evaluation of alternative pathway and factor B haemolytic activities in patients with systemic lupus erythematosus: correlations with the alternative pathway regulatory proteins.

Authors: M T Aguado; L H Perrin; R Ramirez; P A Miescher; P H Lambert
Journal: Clin Exp Immunol Date: 1980-12 Impact factor: 4.330