Literature DB >> 4362811

Picrotoxin antagonism of gamma-aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra.

A R Crossman, R J Walker, G N Woodruff.   

Abstract

Neurones in the substantia nigra of the rat, anaesthetized with urethane, are inhibited both by electrical stimulation of the ipsilateral caudate nucleus and by iontophoretically applied gamma-aminobutyric acid (GABA). Iontophoretically applied picrotoxin reversibly blocks both of these inhibitory responses. These results are consistent with the hypothesis that GABA is the transmitter released by the inhibitory striato-nigral pathway.

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Year:  1973        PMID： 4362811      PMCID： PMC1776601          DOI： 10.1111/j.1476-5381.1973.tb08546.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  The distribution of glutamic decarboxylase in the nervous system of the rhesus monkey.

Authors:  R W ALBERS; R O BRADY
Journal:  J Biol Chem       Date:  1959-04       Impact factor: 5.157

2.  Distribution of glutamic acid decarboxylase activity in human brain.

Authors:  P B MUELLER; H LANGEMANN
Journal:  J Neurochem       Date:  1962 Jul-Aug       Impact factor: 5.372

3.  Monosynaptic inhibition of neurons of the substantia nigra by caudato-nigral fibers.

Authors:  M Yoshida; W Precht
Journal:  Brain Res       Date:  1971-09-10       Impact factor: 3.252

4.  Blockage of caudate-evoked inhibition of neurons in the substantia nigra by picrotoxin.

Authors:  W Precht; M Yoshida
Journal:  Brain Res       Date:  1971-09-10       Impact factor: 3.252

5.  Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 1. Regional distribution of GABA in rabbit, rat, guinea pig and baboon CNS.

Authors:  Y Okada; C Nitsch-Hassler; J S Kim; I J Bak; R Hassler
Journal:  Exp Brain Res       Date:  1971-11-30       Impact factor: 1.972

6.  -aminobutyric acid and a caudato-nigral inhibition.

Authors:  P Feltz
Journal:  Can J Physiol Pharmacol       Date:  1971-12       Impact factor: 2.273

7.  Micromethods in neuropharmacology: an approach to the study of anesthetics.

Authors:  G C Salmoiraghi; F Weight
Journal:  Anesthesiology       Date:  1967 Jan-Feb       Impact factor: 7.892

8.  Electrophysiological analysis of reciprocal caudato-nigral relations.

Authors:  T L Frigyesi; D P Purpura
Journal:  Brain Res       Date:  1967-11       Impact factor: 3.252

9.  Regional distribution of gamma-aminobutyric acid (GABA) in brain of the rhesus monkey.

Authors:  S Fahn; L J Côté
Journal:  J Neurochem       Date:  1968-03       Impact factor: 5.372
  9 in total
  11 in total

1.  Gas exchange of single red blood cells within secondary lamellae of fish gills.

Authors:  G M Hughes; T Koyama
Journal:  J Physiol       Date:  1975-03       Impact factor: 5.182

2.  Effects of peripheral and local administration of picrotoxin on the release of newly synthesized 3H-dopamine in the caudate nucleus of the cat.

Authors:  A Cheramy; A Nieoullon; J Glowinski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-03       Impact factor: 3.000

Review 3.  The biochemistry of the basal ganglia and Parkinson's disease.

Authors:  G Curzon
Journal:  Postgrad Med J       Date:  1977-12       Impact factor: 2.401

4.  Caudate stimulation and substantia nigra activity in the rat.

Authors:  A Dray; T J Gonye; N R Oakley
Journal:  J Physiol       Date:  1976-08       Impact factor: 5.182

5.  Tetanus toxin and synaptic inhibition in the substantia nigra and striatum of the rat.

Authors:  J Davies; P Tongroach
Journal:  J Physiol       Date:  1979-05       Impact factor: 5.182

6.  d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway.

Authors:  B S Bunney; G K Aghajanian
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-10       Impact factor: 3.000

7.  Role of globus pallidus and substantia nigra efferent pathways in striatally evoked head turning in the rat.

Authors:  L A Lee; P Slater
Journal:  Exp Brain Res       Date:  1981       Impact factor: 1.972

8.  Motor activity of rats following intracerebral injections of drugs influencing GABA mechanisms.

Authors:  H Wachtel; N E Andén
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-04       Impact factor: 3.000

9.  Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): evidences for the existence of branched neurons.

Authors:  J M Deniau; C Hammond; A Riszk; J Feger
Journal:  Exp Brain Res       Date:  1978-07-14       Impact factor: 1.972

10.  Neurochemical changes in rat striatum and substantia nigra following drug administration : Evidence for an amino acid-dopamine-acetylcholine link.

Authors:  P J Roberts; H Kapur
Journal:  Neurochem Res       Date:  1977-10       Impact factor: 3.996
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