Literature DB >> 24209

The biochemistry of the basal ganglia and Parkinson's disease.

G Curzon.   

Abstract

The metabolic pathways for five transmitters in the basal ganglia are briefly described; the results of determinations of their concentrations, of their rate-limiting enzymes and of their degradation products are summarized. The changes found in Parkinson's disease are described. While dopamine synthesis in the basal ganglia is defective in this condition, abnormalities of other transmitters occur, and their possible significance is discussed.

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Year:  1977        PMID： 24209      PMCID： PMC2496787          DOI： 10.1136/pgmj.53.626.719

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  25 in total

1.  Immunohistochemical localization of choline acetyltransferase containing neostriatal neurons and their relationship with dopaminergic synapses.

Authors:  T Hattori; V K Singh; E G McGeer; P L McGeer
Journal:  Brain Res       Date:  1976-01-30       Impact factor: 3.252

2.  Rotational behavior induced in rats by intranigral picrotoxin.

Authors:  D Tarsy; C Pycock; B Meldrum; C D Marsden
Journal:  Brain Res       Date:  1975-05-16       Impact factor: 3.252

3.  SUBSTANTIA NIGRA AND PARKINSONISM.

Authors:  F A METTLER
Journal:  Arch Neurol       Date:  1964-11

4.  DEMONSTRATION AND MAPPING OUT OF NIGRO-NEOSTRIATAL DOPAMINE NEURONS.

Authors:  N E ANDEN; A CARLSSON; A DAHLSTROEM; K FUXE; N A HILLARP; K LARSSON
Journal:  Life Sci (1962)       Date:  1964-06

5.  The brain-stem lesions in Parkinsonism.

Authors:  J G GREENFIELD; F D BOSANQUET
Journal:  J Neurol Neurosurg Psychiatry       Date:  1953-11       Impact factor: 10.154

6.  Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data.

Authors:  A R Cools; J M Van Rossum
Journal:  Psychopharmacologia       Date:  1976-02-02

7.  A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain.

Authors:  D M Jackson; N E Andén; A Dahlström
Journal:  Psychopharmacologia       Date:  1975-12-31

8.  Enzymes associated with the metabolism of catecholamines, acetylcholine and gaba in human controls and patients with Parkinson's disease and Huntington's chorea.

Authors:  P L McGeer; E G McGeer
Journal:  J Neurochem       Date:  1976-01       Impact factor: 5.372

9.  [Distribution of 5-hydroxytryptamine (serotonin) in the human brain and its behavior in patients with Parkinson's syndrome].

Authors:  H BERNHEIMER; W BIRKMAYER; O HORNYKIEWICZ
Journal:  Klin Wochenschr       Date:  1961-10-15

10.  [Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system].

Authors:  H EHRINGER; O HORNYKIEWICZ
Journal:  Klin Wochenschr       Date:  1960-12-15
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  3 in total

Review 1.  α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.

Authors:  Maryka Quik; Susan Wonnacott
Journal:  Pharmacol Rev       Date:  2011-12       Impact factor: 25.468

Review 2.  Physiology of abnormal movements.

Authors:  J Marks
Journal:  Postgrad Med J       Date:  1977-12       Impact factor: 2.401

3.  A comparison of facial emotion processing in neurological and psychiatric conditions.

Authors:  Benoit Bediou; Jérôme Brunelin; Thierry d'Amato; Shirley Fecteau; Mohamed Saoud; Marie-Anne Hénaff; Pierre Krolak-Salmon
Journal:  Front Psychol       Date:  2012-04-03
  3 in total

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