Literature DB >> 4362635

Alteration of vein cyclic 3':5' nucleotide concentrations during changes in contractility.

E W Dunham, M K Haddox, N D Goldberg.   

Abstract

The relative changes in vascular tissue levels of cyclic 3':5'-guanosine monophosphate (cGMP) and cyclic 3':5'-adenosine monophosphate (cAMP) were determined in bovine and canine vein strips that were quickfrozen during changes in contractility elicited by prostaglandins (PG) or isoproterenol. Prostaglandin F(2alpha)-induced venoconstriction was associated with increased vascular tissue levels of cGMP and increased ratios of cGMP to cAMP concentrations, but no consistent qualitative change in cAMP levels. In contrast, vein cAMP concentrations were increased during administration of the vasodilators PGE(2) and isoproterenol. The results suggest possible opposing roles for the two cyclic nucleotides in vasomotion.

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Year:  1974        PMID： 4362635      PMCID： PMC388105          DOI： 10.1073/pnas.71.3.815

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Cyclic AMP and smooth muscle function.

Authors:  L Triner; G G Nahas; Y Vulliemoz; N T Overweg; M Verosky; D V Habif; S H Ngai
Journal:  Ann N Y Acad Sci       Date:  1971-12-30       Impact factor: 5.691

2.  Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs.

Authors:  W R Kukovetz; G Pöch
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1970

3.  [Mechanism of action of papaverine on isolated coronary vessels].

Authors:  W R Kukovetz; H Juan; G Pöch
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1969

4.  Cyclic phosphodiesterase activity and the action of papaverine.

Authors:  L Triner; Y Vulliemoz; I Schwartz; G G Nahas
Journal:  Biochem Biophys Res Commun       Date:  1970-07-13       Impact factor: 3.575

5.  Effects of prostaglandins on adenosine 3',5'-monophosphate levels in fat and other tissues.

Authors:  R W Butcher; C E Baird
Journal:  J Biol Chem       Date:  1968-04-25       Impact factor: 5.157

6.  Prostaglandins and consecutive vascular segments of the canine hindlimb.

Authors:  R A Greenberg; H V Sparks
Journal:  Am J Physiol       Date:  1969-03

7.  Venous responses to prostaglandin F2 alpha.

Authors:  A L Mark; P G Schmid; J W Eckstein; M G Wendling
Journal:  Am J Physiol       Date:  1971-01

8.  A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate.

Authors:  F Murad; V Manganiello; M Vaughan
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

9.  Cyclic adenosine monophosphate: potassium-dependent action on vascular smooth muscle membrane potential.

Authors:  A V Somlyo; G Haeusler; A P Somlyo
Journal:  Science       Date:  1970-07-31       Impact factor: 47.728

10.  A protein binding assay for adenosine 3':5'-cyclic monophosphate.

Authors:  A G Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205
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  20 in total

1.  Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP.

Authors:  K D Schultz; E Böhme; V A Kreye; G Schultz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-01       Impact factor: 3.000

2.  Proceedings: Variations in cGMP and cAMP levels in rat uterine smooth muscle induced by carbachol, PGF2alpha and changes in ionic composition.

Authors:  G A d'Auriac; M Worcel
Journal:  Br J Pharmacol       Date:  1975-06       Impact factor: 8.739

3.  Estrogen-directed synthesis of specific prostaglandins in uterus.

Authors:  E A Ham; V J Cirillo; M E Zanetti; F A Kuehl
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

4.  Effects of manganese on cyclic GMP levels in the rat ductus deferens.

Authors:  K D Schultz; K Schultz; G Schultz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-07       Impact factor: 3.000

5.  Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate in isolated fat cells of rat.

Authors:  T Asakawa; J Ruiz; R J Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

6.  Alterations of pulmonary vascular resistance and pulmonary cyclic nucleotide metabolism in the hypoxic pig.

Authors:  E Kaukel; W Beier; K Lanser; V Sill
Journal:  Basic Res Cardiol       Date:  1977 Sep-Oct       Impact factor: 17.165

7.  A promoting action of cyclic GMP on contractions of guinea-pig vas deferens.

Authors:  J E Wikberg; R G Andersson
Journal:  Experientia       Date:  1978-06-15

Review 8.  The role of prostaglandins in altered leukocyte function in multiple sclerosis.

Authors:  P Dore-Duffy; S Y Ho; M Longo
Journal:  Springer Semin Immunopathol       Date:  1985

9.  Release of prostaglandins from the isolated frog ventricle and associated changes in endogenous cyclic nucleotide levels.

Authors:  F W Flitney; J Singh
Journal:  J Physiol       Date:  1980-07       Impact factor: 5.182

Review 10.  Cardiovascular risks and benefits of perioperative nonsteroidal anti-inflammatory drug treatment.

Authors:  F Camu; C Van Lersberghe; M H Lauwers
Journal:  Drugs       Date:  1992       Impact factor: 9.546
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