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Literature DB >> 4357515

Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells.

Abstract

Treatment of Epstein-Barr virus (EBV) negative somatic cell hybrids with 5'-iododeoxyuridine (IUdR) induced synthesis of EBV antigens and virus particles. When dibutyryl cAMP (Bt(2)-cAMP) was present in medium after exposure of cultures to IUdR, the incidence of cells synthesizing EBV early and virus capsid antigens was increased. The time necessary for appearance of EBV particles after induction by IUdR was significantly reduced in the presence of Bt(2)-cAMP. This enhancement was evident to a lesser degree with 3':5' cAMP than with Bt(2)-cAMP and did not occur with any other of the related compounds tested. The response observed was dose dependent. Untreated (no IUdR) EBV negative hybrid cells exposed to Bt(2)-cAMP also synthesized EBV antigens. The concentration of intracellular cAMP may act as one of the control mechanisms selecting for gene expression in this system.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1973 PMID： 4357515 PMCID： PMC356786

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

1. Activation of Epstein-Barr virus by 5-bromodeoxyuridine in "virus-free" human cells (complement-fixing antigen-immunofluorescence-leukocytes).

Authors: P Gerber
Journal: Proc Natl Acad Sci U S A Date: 1972-01 Impact factor: 11.205

2. Epstein-Barr virus-associated antigens in non-producing clones of human lymphoblastoid cell lines.

Authors: K Sugawara; F Mizuno; T Osato
Journal: Nat New Biol Date: 1972-10-25

3. The effect of dibutyryl cyclic AMP on transformation by oncogenic viruses.

Authors: B J Smith; V Defendi; N M Wigglesworth
Journal: Virology Date: 1973-01 Impact factor: 3.616

4. Hybridization of Burkitt lymphoblastoid cells.

Authors: R Glaser; F J O'Neill
Journal: Science Date: 1972-06-16 Impact factor: 47.728

5. Persistence of a repressed Epstein-Barr virus genome in Burkitt lymphoma cells made resistant to 5-bromodeoxyuridine.

Authors: B Hampar; J G Derge; L M Martos; J L Walker
Journal: Proc Natl Acad Sci U S A Date: 1971-12 Impact factor: 11.205

6. A mutation in a rous sarcoma virus gene that controls adenosine 3',5'-monophosphate levels and transformation.

Authors: J Otten; J Bader; G S Johnson; I Pastan
Journal: J Biol Chem Date: 1972-03-10 Impact factor: 5.157

7. Further changes in differentiation state accompanying the conversion of Chinese hamster cells of fibroblastic form by dibutyryl adenosine cyclic 3':5'-monophosphate and hormones.

Authors: A W Hsie; C Jones; T T Puck
Journal: Proc Natl Acad Sci U S A Date: 1971-07 Impact factor: 11.205

8. An anomalous effect of theophylline on ACTH and adenosine 3',5'-monophosphate stimulation.

Authors: I D Halkerston; M Feinstein; O Hechter
Journal: Proc Soc Exp Biol Med Date: 1966-07

9. Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lymphoblastoid cells.

Authors: R Glaser; F Rapp
Journal: J Virol Date: 1972-08 Impact factor: 5.103

10. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives.

Authors: G S Johnson; R M Friedman; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1971-02 Impact factor: 11.205

9 in total

Review 4. Papovaviral persistent infections.

Authors: L C Norkin
Journal: Microbiol Rev Date: 1982-12

Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells.

1. Activation of Epstein-Barr virus by 5-bromodeoxyuridine in "virus-free" human cells (complement-fixing antigen-immunofluorescence-leukocytes).

2. Epstein-Barr virus-associated antigens in non-producing clones of human lymphoblastoid cell lines.

3. The effect of dibutyryl cyclic AMP on transformation by oncogenic viruses.

4. Hybridization of Burkitt lymphoblastoid cells.

5. Persistence of a repressed Epstein-Barr virus genome in Burkitt lymphoma cells made resistant to 5-bromodeoxyuridine.

6. A mutation in a rous sarcoma virus gene that controls adenosine 3',5'-monophosphate levels and transformation.

7. Further changes in differentiation state accompanying the conversion of Chinese hamster cells of fibroblastic form by dibutyryl adenosine cyclic 3':5'-monophosphate and hormones.

8. An anomalous effect of theophylline on ACTH and adenosine 3',5'-monophosphate stimulation.

9. Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lymphoblastoid cells.

10. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives.

Review 1. Oncogenic properties of human viruses.

2. Interaction between cyclic nucleotides and herpes simplex viruses: productive infection.

3. Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons.

Review 4. Papovaviral persistent infections.

5. Reversible repression and activation of measles virus infection in neural cells.

6. Neoplasms, differentiations and mutations.

7. [Intracellular cyclic AMP in vesicular stomatitis or Sendaï virus infected cells (author's transl)].

Review 8. Are viruses important in carcinogenesis?

9. Cyclic AMP regulation of mammary tumor virus production.