| Literature DB >> 4355862 |
J F Morrow, P Berg, T J Kelly, A M Lewis.
Abstract
The simian virus 40 (SV40) DNA segment in the nondefective adenovirus 2-SV40 hybrid, Ad2(+)ND(4), is colinear with the segment between 0.11 and 0.59 SV40 fractional length from the site at which the R(1) restriction endonuclease cleaves SV40 DNA. This specifies the region of the SV40 DNA molecule which induces the early SV40 antigens: U antigen, tumor specific transplantation antigen, and T antigen. A variant of Ad2(+)ND(4), called Ad2(+)ND(4del), was found which has a deletion of the DNA segment between 0.50 and 0.57 SV40 fractional length from the R(1) endonuclease cleavage point.Entities:
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Year: 1973 PMID: 4355862 PMCID: PMC356674
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103