Literature DB >> 4355681

Collagen synthesis: localization of prolyl hydroxylase in tendon cells detected with ferritin-labeled antibodies.

B R Olsen, R A Berg, Y Kishida, D J Prockop.   

Abstract

An improved procedure was employed for linking ferritin to antibodies against prolyl hydroxylase, the enzyme that synthesizes the hydroxyproline in collagen. By electron microscopy, the enzyme was then found to be localized in cisternae of the rough endoplasmic reticulum of embryonic tendon cells; this indicates that hydroxylation of proline occurs while newly synthesized polypeptides are fed into the cisternae.

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Year:  1973        PMID： 4355681     DOI： 10.1126/science.182.4114.825

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

1.  Biochemical characteristics and biological significance of the genetically-distinct collagens.

Authors:  E J Miller
Journal:  Mol Cell Biochem       Date:  1976-12-10       Impact factor: 3.396

2.  The effects of ascorbic acid deficiency on calcium and collagen metabolism in cultured fetal rat bones.

Authors:  T L Chen; L G Raisz
Journal:  Calcif Tissue Res       Date:  1975

3.  Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Changes in prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase activities.

Authors:  J Risteli; K I Kivirikko
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857

4.  Immunolocalization of prolyl 4-hydroxylase in fibroblasts cultured from Tenon's capsule of humans.

Authors:  S Saika; A Ooshima; O Yamanaka; O Tonoe; Y Okada; Y Ohnishi; M Kimura
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-04       Impact factor: 3.117

5.  Prolyl 4-hydroxylase: molecular cloning and the primary structure of the alpha subunit from chicken embryo.

Authors:  J A Bassuk; W W Kao; P Herzer; N L Kedersha; J Seyer; J A DeMartino; B L Daugherty; G E Mark; R A Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

6.  Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro.

Authors:  S Saika; A Ooshima; O Yamanaka; Y Okada; S Tanaka; Y Ohnishi
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-08       Impact factor: 3.117

7.  Collagen biosynthesis. Characterization of subcellular fractions from embyonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxylases.

Authors:  R Harwood; M E Grant; D S Jackson
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

8.  Ferritin-conjugated antibodies used for labeling of organelles involved in the cellular synthesis and transport of procollagen.

Authors:  B R Olsen; D J Prockop
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

Review 9.  The localization of enzymes in tissue sections by immuno-histochemistry. Conventional antibody and mixed aggregation techniques.

Authors:  E D Wachsmuth
Journal:  Histochem J       Date:  1976-05

10.  The subcellular fractionation of embryonic chick tendon and cartilage cells: a re-examination.

Authors:  M E Grant; D S Jackson
Journal:  Biochem J       Date:  1979-05-15       Impact factor: 3.857
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