Literature DB >> 4352788

Demonstration of a glucocorticoid hormone-receptor complex in the cytoplasm of a hormone-responsive tumour.

D G Gardner, J L Wittliff.   

Abstract

Specific substances binding [(3)H]-triamcinolone acetonide have been demonstrated in the cytoplasmic fraction of the R3230AC mammary carcinoma using sucrose gradient centrifugation. These receptors, which exhibit sedimentation coefficients of 8-9 Svedberg units, are relatively specific for glucocorticoid ligands and possess a high affinity for triamcinolone acetonide (K(d)∼7 × 10(-8) mol/1).

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Year:  1973        PMID: 4352788      PMCID: PMC2008813          DOI: 10.1038/bjc.1973.55

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  7 in total

1.  BIOCHEMICAL AND MORPHOLOGIC PROPERTIES OF A NEW LACTATING MAMMARY TUMOR LINE IN THE RAT.

Authors:  R HILF; I MICHEL; C BELL; J J FREEMAN; A BORMAN
Journal:  Cancer Res       Date:  1965-04       Impact factor: 12.701

2.  Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans.

Authors:  J L Wittliff; R Hilf; W F Brooks; E D Savlov; T C Hall; R A Orlando
Journal:  Cancer Res       Date:  1972-09       Impact factor: 12.701

Review 3.  Will the best model of breast cancer please come forward?

Authors:  R Hilf
Journal:  Natl Cancer Inst Monogr       Date:  1971-12

4.  Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro.

Authors:  A Munck; T Brinck-Johnsen
Journal:  J Biol Chem       Date:  1968-11-10       Impact factor: 5.157

5.  Acquired hormonal dependence of milk protein synthesis in mammary carcinoma cells.

Authors:  R W Turkington; M Riddle
Journal:  Endocrinology       Date:  1969-05       Impact factor: 4.736

6.  Milk-like fluid in a mammary adenocarcinoma: biochemical characterization.

Authors:  R Hilf
Journal:  Science       Date:  1967-02-17       Impact factor: 47.728

7.  Hormonal stimulation of lactose synthetase in mammary carcinoma.

Authors:  W L McGuire
Journal:  Science       Date:  1969-09-05       Impact factor: 47.728

  7 in total
  1 in total

Review 1.  [Current status in the treatment of breast cancer. I. Endocrine management--change of concepts and outlook for the future (author's transl)].

Authors:  U Jehn; H Sauer; W Wilmanns
Journal:  Klin Wochenschr       Date:  1979-09-17
  1 in total

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