Literature DB >> 4348463

1 -Hydroxy derivative of vitamin D 3 : a highly potent analog of 1 ,25-dihydroxyvitamin D 3 .

M F Holick, E J Semmler, H K Schnoes, H F DeLuca.   

Abstract

The 1alpha-hydroxy derivative of vitamin D(3) has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D(3) in the stimulation of intestinal calcium transport and bone calcium mobilization in normnal and anephric rats. Because the 1alpha-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1alpha,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypopara-thyroidism.

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Year:  1973        PMID： 4348463     DOI： 10.1126/science.180.4082.190

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  25-Hydroxyvitamin D3 regulation.

Authors:  M B Clark; J T Potts
Journal:  Calcif Tissue Res       Date:  1977-05

Review 2.  The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).

Authors:  Luisella Cianferotti; Claudio Cricelli; John A Kanis; Ranuccio Nuti; Jean-Y Reginster; Johann D Ringe; Rene Rizzoli; Maria Luisa Brandi
Journal:  Endocrine       Date:  2015-05-01       Impact factor: 3.633

3.  The effects of 1alpha-OH cholecalciferol on calcium, magnesium and phosphorus metabolism in dairy heifers, and its potential value for the prevention of milk fever.

Authors:  B F Sansom; W M Allen; D C Davies; M N Hoare; J R Stenton; M J Vagg
Journal:  Calcif Tissue Res       Date:  1977-05

4.  Treatment of psoriasis vulgaris by oral administration of 1 alpha-hydroxyvitamin D3--open-design study.

Authors:  S Morimoto; K Yoshikawa; T Kozuka; Y Kitano; S Imanaka; K Fukuo; E Koh; T Onishi; Y Kumahara
Journal:  Calcif Tissue Int       Date:  1986-09       Impact factor: 4.333

5.  Jejunal and ileal absorption in patients with chronic renal disease. Effect of 1alpha-hydroxycholecalciferol.

Authors:  P Vergne-Marini; T F Parker; C Y Pak; A R Hull; H F DeLuca; J S Fordtran
Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

6.  Comparison of effects of 1 alpha-hydroxy-vitamin D3 and 1,25-dihydroxy-vitamin D3 in man.

Authors:  A S Brickman; J W Coburn; G R Friedman; W H Okamura; S G Massry; A W Norman
Journal:  J Clin Invest       Date:  1976-06       Impact factor: 14.808

7.  The effects of vitamin D analogues on bone resorption.

Authors:  J J Reynolds; M F Holick; H F DeLuca
Journal:  Calcif Tissue Res       Date:  1974

8.  Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3.

Authors:  D D Bikle; R N Empson; R L Morrissey; D T Zolock; T J Bucci; R H Herman; M M Pechet
Journal:  Calcif Tissue Int       Date:  1980       Impact factor: 4.333

9.  Synthesis of 1 alpha-hydroxy[7-3H]cholecalciferol and its metabolism in the chick.

Authors:  S Edelstein; D Noff; D Freeman; M Sheves; Y Mazur
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857

10.  Treatment of secondary hyperparathyroidism in haemodialysis patients: a randomised clinical trial comparing paricalcitol and alfacalcidol.

Authors:  Ditte Hansen; Lisbet Brandi; Knud Rasmussen
Journal:  BMC Nephrol       Date:  2009-09-24       Impact factor: 2.388
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