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Literature DB >> 4340154

Effect of norepinephrine on glucose metabolism in glioblastoma and neuroblastoma cells in cell culture.

Abstract

The addition of norepinephrine to cultured glioblastoma cells results in an inhibition of uptake of radioactivity from D-[2-(3)H]glucose, D-[1-(14)C]glucose, D-[2-(14)C]glucose, and D-[6-(14)C]glucose. In addition, if the glioblastoma cells are previously labeled with these substrates, norepinephrine causes an increase in the release of radioactivity. These effects were not observed with cultured neuroblastoma cells. It is suggested that the breakdown of glycogen is activated by norepinephrine as a result of an increase in 3':5'-cyclic AMP.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1972 PMID： 4340154 PMCID： PMC426776 DOI： 10.1073/pnas.69.7.1677

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

5 in total

1. A glia-neural theory of brain function.

Authors: R GALAMBOS
Journal: Proc Natl Acad Sci U S A Date: 1961-01-15 Impact factor: 11.205

2. Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.

Authors: A G Gilman; M Nirenberg
Journal: Proc Natl Acad Sci U S A Date: 1971-09 Impact factor: 11.205

3. Differentiated rat glial cell strain in tissue culture.

Authors: P Benda; J Lightbody; G Sato; L Levine; W Sweet
Journal: Science Date: 1968-07-26 Impact factor: 47.728

4. Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine.

Authors: R B Clark; J P Perkins
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

Effect of norepinephrine on glucose metabolism in glioblastoma and neuroblastoma cells in cell culture.

1. A glia-neural theory of brain function.

2. Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.

3. Differentiated rat glial cell strain in tissue culture.

4. Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine.

5. A kinetic study of the neuronglia relationship.

Review 1. Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.

2. Neuronal and glial enzyme studies in cell culture.

Review 3. Cellular composition of a cerebral hemisphere primary culture.

4. Uptake and release of choline in cultures of human glioma cells.

5. Norepinephrine inhibits migration and invasion of human glioblastoma cell cultures possibly via MMP-11 inhibition.