Literature DB >> 4339883

Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines.

B G Benfey.   

Abstract

1. Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.2. Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.3. This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.

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Year:  1971        PMID： 4339883      PMCID： PMC1665713          DOI： 10.1111/j.1476-5381.1971.tb07211.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  12 in total

1.  The adrenergic receptors of the coronary circulation in the isolated dog heart.

Authors:  E Kabela; J Jalife; C Peon; L Cros; R Mendez
Journal:  Arch Int Pharmacodyn Ther       Date:  1969-10

2.  Pharmacological characteristics of adrenergic receptors.

Authors:  R F Furchgott
Journal:  Fed Proc       Date:  1970 Jul-Aug

3.  Effects of epinephrine on cardiac cyclic 3',5'-AMP, phosphorylase kinase, and phosphorylase.

Authors:  D H Namm; S E Mayer
Journal:  Mol Pharmacol       Date:  1968-01       Impact factor: 4.436

4.  Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.

Authors:  D G Wenzel; J L Su
Journal:  Arch Int Pharmacodyn Ther       Date:  1966-04

5.  A simple, sensitive method for the assay of adenyl cyclase.

Authors:  G Krishna; B Weiss; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1968-10       Impact factor: 4.030

6.  Hormonal regulation of myocardial adenosine 3',5'-monophosphate.

Authors:  P J Laraia; W Reddy
Journal:  Biochim Biophys Acta       Date:  1969-04-01

7.  The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.

Authors:  G A Robison; R W Butcher; I Oye; H E Morgan; E W Sutherland
Journal:  Mol Pharmacol       Date:  1965-09       Impact factor: 4.436

8.  An assay for adenyl cyclase.

Authors:  J M Streeto; W J Reddy
Journal:  Anal Biochem       Date:  1967-12       Impact factor: 3.365

9.  Kinetics of cyclic adenosine monophosphate changes in rat heart following epinephrine administration.

Authors:  W Y Cheung; J R Williamson
Journal:  Nature       Date:  1965-08-28       Impact factor: 49.962

10.  Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.

Authors:  B G Benfey; D R Varma
Journal:  Br J Pharmacol Chemother       Date:  1967-08
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  12 in total

1.  Studies on the positive inotropic effect of phenylephrine: a comparison with isoprenaline.

Authors:  F Ledda; P Marchetti; A Mugelli
Journal:  Br J Pharmacol       Date:  1975-05       Impact factor: 8.739

2.  Comparison of the mechanisms underlying the positive inotropic actions of dopamine, adrenaline and isoprenaline on the isolated rabbit papillary muscle.

Authors:  H J Schümann; S Motomura; M Endoh; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-04       Impact factor: 3.000

3.  Influence of papaverine and isoprenaline on contractility and cyclic AMP level of left guinea-pig atria at different rates of beat.

Authors:  D Reinhardt; W Roggenbach; O E Brodde; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-08       Impact factor: 3.000

4.  On the presence and distribution of alpha-adrenoceptors in the heart of various mammalian species.

Authors:  J Wagner; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-05       Impact factor: 3.000

5.  Effect of catecholamines, histamine and oxyfedrine on isotonic contraction and cyclic AMP in the guinea-pig heart.

Authors:  W R Kukovetz; G Pöch; A Wurm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

6.  Characterization of -adrenoceptors in the myocardium.

Authors:  B G Benfey
Journal:  Br J Pharmacol       Date:  1973-05       Impact factor: 8.739

7.  Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by alpha- and beta-adrenoceptors.

Authors:  H J Schümann; M Endo; J Wagner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

8.  H1 - and H2-receptor mediated responses to histamine on contractility and cyclic AMP of atrial and papillary muscles from guinea-pig hearts.

Authors:  D Reinhardt; U Schmidt; O E Brodde; H J Schümann
Journal:  Agents Actions       Date:  1977-03

9.  Theophylline and phenylephrine effects on cardiac relaxation.

Authors:  B G Benfey
Journal:  Br J Pharmacol       Date:  1977-01       Impact factor: 8.739

10.  Dissociation of 5-hydroxytryptamine effects on myocardial contractility and cyclic AMP accumulation.

Authors:  B G Benfey; J Cohen; G Kunos; I Vermes-Kunos
Journal:  Br J Pharmacol       Date:  1974-04       Impact factor: 8.739
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