Literature DB >> 4146762

Characterization of -adrenoceptors in the myocardium.

B G Benfey.   

Abstract

1. In the driven rabbit left atrium alpha-adrenoceptors mediate the inotropic effect of phenylephrine and the prolongation of functional refractory period by sympathomimetic amines.2. These receptors are highly sensitive to blockade by phentolamine and phenoxybenzamine.3. Prolongation of functional refractory period is greater with the secondary amines, phenylephrine, adrenaline and epinine, than with the primary amines, norphenylephrine, noradrenaline and dopamine.

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Year:  1973        PMID： 4146762      PMCID： PMC1776086          DOI： 10.1111/j.1476-5381.1973.tb08230.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  17 in total

1.  Effect of phenylephrine on cardiac contractility and adenyl cyclase activity.

Authors:  B G Benfey; T Carolin
Journal:  Can J Physiol Pharmacol       Date:  1971-06       Impact factor: 2.273

2.  The adrenergic receptors of the coronary circulation in the isolated dog heart.

Authors:  E Kabela; J Jalife; C Peon; L Cros; R Mendez
Journal:  Arch Int Pharmacodyn Ther       Date:  1969-10

3.  Combinations of alpha and beta adrenergic blockers in isolated guinea-pig atria.

Authors:  R D Krell; P N Patil
Journal:  J Pharmacol Exp Ther       Date:  1969-12       Impact factor: 4.030

4.  Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.

Authors:  W C Govier
Journal:  J Pharmacol Exp Ther       Date:  1968-01       Impact factor: 4.030

5.  Myocardial alpha and beta adrenergic receptors as demonstrated by atrial functional refractory-period changes.

Authors:  W C Govier; N C Mosal; P Whittington; A H Broom
Journal:  J Pharmacol Exp Ther       Date:  1966-11       Impact factor: 4.030

6.  Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.

Authors:  D G Wenzel; J L Su
Journal:  Arch Int Pharmacodyn Ther       Date:  1966-04

7.  Blockade of the cardiac action of phenylephrine by bretylium or cocaine.

Authors:  C S Yoo; W C Lee
Journal:  J Pharmacol Exp Ther       Date:  1970-04       Impact factor: 4.030

8.  The pharmacological differentiation of adrenergic receptors.

Authors:  R F Furchgott
Journal:  Ann N Y Acad Sci       Date:  1967-02-10       Impact factor: 5.691

9.  Prolongation of the myocardial functional refractory period by phenylephrine.

Authors:  W C Govier
Journal:  Life Sci       Date:  1967-07-01       Impact factor: 5.037

10.  Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.

Authors:  B G Benfey; D R Varma
Journal:  Br J Pharmacol Chemother       Date:  1967-08
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  15 in total

1.  Studies on the positive inotropic effect of phenylephrine: a comparison with isoprenaline.

Authors:  F Ledda; P Marchetti; A Mugelli
Journal:  Br J Pharmacol       Date:  1975-05       Impact factor: 8.739

2.  Influence of temperature on the positive inotropic effects mediated by alpha-and-beta-adrenoceptors in the isolated rabbit papillary muscle.

Authors:  M Endoh; J Wagner; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

3.  Frequency-dependence of the positive inotropic effect of methoxamine and naphazoline mediated by alpha-Adrenoceptors in the isolated rabbit papillary muscle.

Authors:  M Endoh; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

Review 4.  [Alpha-adrenoceptors in the myocardium: incidence and functional significance].

Authors:  A Mügge
Journal:  Klin Wochenschr       Date:  1985-11-04

5.  The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase in c-AMP.

Authors:  R Brückner; I Hackbarth; T Meinertz; B Schmelzle; H Scholz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000

6.  Characterization of adrenoceptors mediating positive inotropic responses in the ventricular myocardium of the dog.

Authors:  M Endoh; T Shimizu; T Yanagisawa
Journal:  Br J Pharmacol       Date:  1978-09       Impact factor: 8.739

7.  Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by alpha- and beta-adrenoceptors.

Authors:  H J Schümann; M Endo; J Wagner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

8.  Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs.

Authors:  J Wagner; D Reinhardt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

9.  Hypersensitivity to methoxamine in atria isolated from streptozotocin-induced diabetic rats.

Authors:  L Canga; L Sterin-Borda
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

10.  Theophylline and phenylephrine effects on cardiac relaxation.

Authors:  B G Benfey
Journal:  Br J Pharmacol       Date:  1977-01       Impact factor: 8.739
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