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Literature DB >> 4338587

Inhibition of sterol biosynthesis by bacitracin.

Abstract

Bacitracin is an inhibitor of the biosynthesis of squalene and sterols from mevalonic acid, C(5)-isopentenyl pyrophosphate, or C(15)-farnesyl pyrophosphate catalyzed by preparations from rat liver. The antibiotic is active at extremely low ratios of antibiotic to substrate. The mechanism of inhibition appears to be the formation of a complex between bacitracin, divalent cation, and C(15)-farnesyl pyrophosphate and other isoprenyl pyrophosphates. It is similar to the formation of the complex with C(55)-isopropenyl pyrophosphate in microbial systems. The toxicity of bacitracin for animal cells could be due in part to the formation of these complexes.

Entities: Chemical Disease Species

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Year: 1972 PMID： 4338587 PMCID： PMC426683 DOI： 10.1073/pnas.69.5.1287

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

8 in total

1. Measurement of protein-binding phenomena by gel filtration.

Authors: J P HUMMEL; W J DREYER
Journal: Biochim Biophys Acta Date: 1962-10-08

2. Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes.

Authors: D S GOODMAN; G POPJAK
Journal: J Lipid Res Date: 1960-07 Impact factor: 5.922

3. Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.

Authors: G Siewert; J L Strominger
Journal: Proc Natl Acad Sci U S A Date: 1967-03 Impact factor: 11.205

4. The incorporation of p-hydroxybenzoate and isopentenyl pyrophosphate into polyprenylphenol precursors of ubiquinone by broken cell preparations of Rhodospirillum rubrum.

Authors: T S Raman; H Rudney; N K Buzzelli
Journal: Arch Biochem Biophys Date: 1969-03 Impact factor: 4.013

5. Dolichol phosphates as acceptors of mannose from guanosine diphosphate mannose in liver systems.

Authors: J B Richards; P J Evans; F W Hemming
Journal: Biochem J Date: 1971-10 Impact factor: 3.857

6. Glucose transfer from dolichol monophosphate glucose: the product formed with endogenous microsomal acceptor.

Authors: N H Behrens; A J Parodi; L F Leloir
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

7. Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate.

Authors: K J Stone; J L Strominger
Journal: Proc Natl Acad Sci U S A Date: 1971-12 Impact factor: 11.205

8. Biosynthesis of the peptidoglycan of bacterial cell walls. I. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate acetylglucosamine for peptidoglycan synthesis by particulate enzymes from Staphylococcus aureus and Micrococcus lysodeikticus.

Authors: J S Anderson; P M Meadow; M A Haskin; J L Strominger
Journal: Arch Biochem Biophys Date: 1966-09-26 Impact factor: 4.013

8 in total

7 in total

1. Pretreatment of pericardial patches with antibiotics does not alter patch healing in vivo.

Authors: Hualong Bai; Go Kuwahara; Mo Wang; Kirstyn E Brownson; Trenton R Foster; Kota Yamamoto; Ying Xing; Alan Dardik
Journal: J Vasc Surg Date: 2014-11-06 Impact factor: 4.268

2. Evidence for a direct effect of bacitracin on cell-mediated insulin degradation in isolated hepatocytes.

Authors: S M Juul; R H Jones
Journal: Biochem J Date: 1982-08-15 Impact factor: 3.857

3. The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum.

Authors: J B Richards; F W Hemming
Journal: Biochem J Date: 1972-11 Impact factor: 3.857

4. Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR.

Authors: Janet M Manson; Stefanie Keis; John M B Smith; Gregory M Cook
Journal: Antimicrob Agents Chemother Date: 2004-10 Impact factor: 5.191