Literature DB >> 4338253

5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats.

M F Holick, M Garabedian, H F DeLuca.   

Abstract

A new compound, 5,6-trans-25-hydroxycholecalciferol, has been synthesized and tested for its biological activity. Like 1,25-dihydroxycholecalciferol, it stimulates intestinal calcium transport in anephric rats, whereas 25-hydroxycholecalciferol does not. But this analog has little if any activity in stimulating mobilization of calcium from the bone of anephric rats.

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Year:  1972        PMID： 4338253     DOI： 10.1126/science.176.4040.1247

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  The role of phosphate in the action of vitamin D on the intestine.

Authors:  S J Birge; R Miller
Journal:  J Clin Invest       Date:  1977-11       Impact factor: 14.808

2.  The effects of vitamin D analogues on bone resorption.

Authors:  J J Reynolds; M F Holick; H F DeLuca
Journal:  Calcif Tissue Res       Date:  1974

Review 3.  Metabolism and action of the hormone vitamin D. Its relation to diseases of calcium homeostasis.

Authors:  J W Coburn; D L Hartenbower; A W Norman
Journal:  West J Med       Date:  1974-07

4.  The effect of 5,6-trans-25-hydroxycholecalciferol in relative vitamin D resistancy.

Authors:  D Kraft; G Offermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-03       Impact factor: 3.000
  4 in total

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