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Literature DB >> 859645

The effect of 5,6-trans-25-hydroxycholecalciferol in relative vitamin D resistancy.

Abstract

The relative vitamin D resistance in patients with chronic renal failure and in those with hypoparathyroidism is due to an impairment of 1-hydroxylation of cholecalciferol. 5,6-trans-25OHCC, which has a similar steric configuration as 1,25(OH)2CC was examined at a daily dose of 18,000 IU fro 14 days in both diseases. Intestinal 47calcium absorption as well as serum calcium level could be normalized in most patients with hypoparathyroidism. The improvement was less in patients with chronic renal failure, suggesting an additional depressing influence of uremia on calcium metabolism.

Entities: Chemical Disease Species

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Year: 1977 PMID： 859645 DOI： 10.1007/BF00508812

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

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References

21 in total

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Authors: A W Norman; R L Johnson; T W Osborn; D A Procsal; S C Carey; M L Hammond; M N Mitra; M R Pirio; A Rego; R M Wing; W H Okamura
Journal: Clin Endocrinol (Oxf) Date: 1976 Impact factor: 3.478

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Authors: R D Hesch; W Gerlach; H V Henning; D Emrich; F Scheler; R Kattermann
Journal: Dtsch Med Wochenschr Date: 1972-11-10 Impact factor: 0.628

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Authors: A S Brickman; J W Coburn; A W Norman
Journal: N Engl J Med Date: 1972-11-02 Impact factor: 91.245

4. Unique biosynthesis by kidney of a biological active vitamin D metabolite.

Authors: D R Fraser; E Kodicek
Journal: Nature Date: 1970-11-21 Impact factor: 49.962

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Authors: J J Reynolds; M F Holick; H F DeLuca
Journal: Calcif Tissue Res Date: 1974

6. Treatment of uremic bone disease. Action of 5,6-trans-25-hydroxycholecalciferol (a vitamin D-analog) in chronic renal failure.

Authors: D von Herrath; K Schaefer; D Kraft; H G Grigoleit; P Koeppe
Journal: Klin Wochenschr Date: 1973-10-01

The effect of 5,6-trans-25-hydroxycholecalciferol in relative vitamin D resistancy.

Review 1. The chemistry and conformational and biological analysis of vitamin D3, its metabolites and analogues.

2. [Studies on intestinal 47 Calcium absorption in healthy subjects and patients with chronic renal failure as well as on the significance of vitamin D 3 or 25-hydroxycholecalciferol therapy in renal osteopathy].

3. Action of 1,25-dihydroxycholecalciferol, a potent, kidney-produced metabolite of vitamin D, in uremic man.

4. Unique biosynthesis by kidney of a biological active vitamin D metabolite.

5. The effects of vitamin D analogues on bone resorption.

6. Treatment of uremic bone disease. Action of 5,6-trans-25-hydroxycholecalciferol (a vitamin D-analog) in chronic renal failure.

7. The early effects of dihydrotachysterol on calcium and phosphorus metabolism in patients with hypoparathyroidism.

8. 1,25 Dihydroxy-vitamin D3 in normal man and patients with renal failure.

9. Treatment of hypoparathyroidism with 1,25-dihydroxycholecalciferol.

10. Radioimmunoassay of human parathyroid hormone in serum.