Literature DB >> 4336690

Metabolism of nicotinamide adenine dinucleotide in human and bovine strainsof Mycobacterium tuberculosis.

L B Kasărov, A G Moat.   

Abstract

A marked difference was found to exist between the nicotinamide adenine dinucleotide (NAD) glycohydrolase activity of human strains of Mycobacterium tuberculosis as compared with bovine strains. Human strains had from 6- to 20-fold higher NAD glycohydrolase activity than bovine strains. This finding explains the accumulation of free nicotinic acid in the culture medium by human strains and not by bovine strains. The biosynthetic intermediates nicotinic acid mononucleotide and deamido-NAD were not degraded by either human or bovine strains of M. tuberculosis; hence these nucleotides do not represent a source of the nicotinic acid accumulated by the human strains.

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Year:  1972        PMID： 4336690      PMCID： PMC247454          DOI： 10.1128/jb.110.2.600-603.1972

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  14 in total

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Authors:  R BONICKE; B P LISBOA
Journal:  Tuberkulosearzt       Date:  1959-06

2.  The metabolism of nicotinic acid in Mycobacteria: a method for differentiating tubercle bacilli of human origin from other Mycobacteria.

Authors:  K KONNO; R KURZMANN; K T BIRD
Journal:  Am Rev Tuberc       Date:  1957-04

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Authors:  Y S HALPERN; N GROSSOWICZ
Journal:  Biochem J       Date:  1957-04       Impact factor: 3.857

4.  Differentiation of human tubercle bacilli from atypical acid-fast bacilli. I. Niacin production of human tubercle bacilli and atypical acid-fast bacilli.

Authors:  K KONNO; R KURZMANN; K T BIRD; A SBARRA
Journal:  Am Rev Tuberc       Date:  1958-04

5.  Differentiation of human tubercle bacilli from atypical acid-fast bacilli. II. Clinical application.

Authors:  K KONNO; R KURZMANN; K T BIRD; A SBARRA
Journal:  Am Rev Tuberc       Date:  1958-04

6.  New chemical method to differentiate human-type tubercle bacilli from other mycobacteria.

Authors:  K KONNO
Journal:  Science       Date:  1956-11-16       Impact factor: 47.728

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Authors:  E KODKICEK; K K REDDI
Journal:  Nature       Date:  1951-09-15       Impact factor: 49.962

8.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

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Authors:  K P Gopinathan; M Sirsi; C S Vaidyanathan
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.857

10.  Biosynthesis of NAD and nicotinic acid by Clostridium butylicum.

Authors:  A J Isquith; A G Moat
Journal:  Biochem Biophys Res Commun       Date:  1966-03-08       Impact factor: 3.575
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  8 in total

1.  Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

Authors:  Helena I Boshoff; Valerie Mizrahi; Clifton E Barry
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

Review 2.  Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems.

Authors:  J W Foster; A G Moat
Journal:  Microbiol Rev       Date:  1980-03

3.  NAD+ auxotrophy is bacteriocidal for the tubercle bacilli.

Authors:  Catherine Vilchèze; Brian Weinrick; Ka-Wing Wong; Bing Chen; William R Jacobs
Journal:  Mol Microbiol       Date:  2010-02-28       Impact factor: 3.501

4.  Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide.

Authors:  J W Foster; D M Kinney; A G Moat
Journal:  J Bacteriol       Date:  1979-03       Impact factor: 3.490

5.  Metabolism of the pyridine nucleotides involved in nicotinamide adenine dinucleotide biosynthesis by Clostridium butylicum.

Authors:  L B Kasărov; A G Moat
Journal:  J Bacteriol       Date:  1973-07       Impact factor: 3.490

6.  Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.

Authors:  Helena I M Boshoff; Xia Xu; Kapil Tahlan; Cynthia S Dowd; Kevin Pethe; Luis R Camacho; Tae-Ho Park; Chang-Soo Yun; Dirk Schnappinger; Sabine Ehrt; Kerstin J Williams; Clifton E Barry
Journal:  J Biol Chem       Date:  2008-05-19       Impact factor: 5.157

7.  Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivation.

Authors:  Xu-De Wang; Jing Gu; Ting Wang; Li-Jun Bi; Zhi-Ping Zhang; Zong-Qiang Cui; Hong-Ping Wei; Jiao-Yu Deng; Xian-En Zhang
Journal:  Mol Microbiol       Date:  2011-11-03       Impact factor: 3.501

8.  Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis.

Authors:  H I Boshoff; V Mizrahi
Journal:  J Bacteriol       Date:  1998-11       Impact factor: 3.490
  8 in total

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