Literature DB >> 433609

Effects of the GABA receptor agonist muscimol on the turnover of brain dopamine and on the motor activity of rats.

N E Andén, M Grabowska-Andén, H Wachtel.   

Abstract

Muscimol (3-hydroxy-5-aminomethylisoxazole) at a high dose (10 mg/kg intraperitoneally) elevated the concentration of brain dopamine in rats, decreased the utilization of dopamine and increased the synthesis of dopamine. The utilization of noradrenaline was acclerated rather than retarded by muscimol. Local application of muscimol to the nucleus accumbens of rats inhibited the motor activity in a dose-dependent manner with only a slight subsequent hyperactivity. The effects are similar to those produced by GABA and they support the view that muscimol is a GABA receptor agonist.

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Year:  1979        PMID： 433609     DOI： 10.1111/j.1600-0773.1979.tb02316.x

Source DB:  PubMed          Journal:  Acta Pharmacol Toxicol (Copenh)        ISSN： 0001-6683


  9 in total

1.  Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain.

Authors:  I Yokoi; T Itoh; K Yufu; K Akiyama; M Satoh; S Murakami; H Kabuto; A Mori
Journal:  Neurochem Res       Date:  1991-10       Impact factor: 3.996

2.  GABA mimetics increase extracellular DOPAC (as measured by in vivo voltammetry) in the rat locus coeruleus.

Authors:  B Scatton; A Serrano
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

Review 3.  The organization and regulation of sleep. A review of the experimental evidence and a novel integrated model of the organizing and regulating apparatus.

Authors:  W P Koella
Journal:  Experientia       Date:  1984-04-15

4.  Further evidence for, and nature of, the facilitatory GABAergic influence on central noradrenergic transmission.

Authors:  T Dennis; O Curet; T Nishikawa; B Scatton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

5.  Effects of muscimol and baclofen on levels of monoamines and their metabolites in the El mouse brain.

Authors:  H Kabuto; I Yokoi; A Mori
Journal:  Neurochem Res       Date:  1988-12       Impact factor: 3.996

6.  Effects of taurine, homotaurine and GABA on hypothalamic and striatal dopamine metabolism.

Authors:  E Panula-Lehto; M Mäkinen; L Ahtee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-07       Impact factor: 3.000

7.  2-Guanidinoethanol increased dopamine release and 3,4-dihydroxyphenylacetic acid content, but not homovanillic acid content in the rat brain: electroneurochemical and enzymological studies.

Authors:  I Yokoi; H Kabuto; K Hukuyama; Y Nishijima; T Itoh; K Yufu; K Akiyama; A Mori
Journal:  Neurochem Res       Date:  1992-07       Impact factor: 3.996

8.  Differential effects of IV and IP muscimol on central dopamine metabolism.

Authors:  A L Gundlach; P M Beart
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

9.  Lack of effects of apomorphine, haloperidol and clozapine on the synthesis and utilization of brain GABA.

Authors:  S Lindgren
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575
  9 in total

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