Literature DB >> 6791208

Differential effects of IV and IP muscimol on central dopamine metabolism.

A L Gundlach, P M Beart.   

Abstract

The effect of IV and IP muscimol on the concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in both the nigrostriatal and mesolimbic dopaminergic pathways has been studied. IV muscimol (2 mg/kg), produced significant decreases in the concentration of DA in both DA systems, while the concentration of DOPAC remained unaltered. However, IP muscimol (5 and 10 mg/kg) caused significant increases in the concentrations of DA or DOPAC in all brain regions examined. Our results suggest differential actions of muscimol on DA metabolism dependent upon the route of administration.

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Year:  1981        PMID： 6791208     DOI： 10.1007/BF00431760

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  17 in total

1.  Evidence for an inhibitory gabergic control of the meso-limbic dopamine neurons: possibility of improving treatment of schizophrenia by combined treatment with neuroleptics and gabergic drugs.

Authors:  K Fuxe; T Hökfelt; A Ljungdahl; L Agnati; O Johansson; M Perez de la Mora
Journal:  Med Biol       Date:  1975-06

2.  Central GABA receptor agonists: comparison of muscimol and baclofen.

Authors:  S R Naik; A Guidotti; E Costa
Journal:  Neuropharmacology       Date:  1976-08       Impact factor: 5.250

3.  Use of 3H-muscimol for GABA receptor studies.

Authors:  S R Snodgrass
Journal:  Nature       Date:  1978-06-01       Impact factor: 49.962

4.  Effect of muscimol, a GABA-mimetic agent, on dopamine metabolism in the mouse brain.

Authors:  G Biggio; M Casu; M G Corda; F Vernaleone; G L Gessa
Journal:  Life Sci       Date:  1977-08-15       Impact factor: 5.037

Review 5.  Regulation of nigrostriatal and tuberoinfundibular-hypophyseal dopaminergic neurons.

Authors:  K E Moore; S M Wuerthele
Journal:  Prog Neurobiol       Date:  1979       Impact factor: 11.685

6.  Modifications of DOPAC levels in the striatum and olfactory tubercles of the rat after muscimol.

Authors:  A Restelli; F Zambotti; L Vicentini; N Zonta; P Mantegazza
Journal:  Pharmacol Res Commun       Date:  1979-01

7.  Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons.

Authors:  B L Waszczak; N Eng; J R Walters
Journal:  Brain Res       Date:  1980-04-21       Impact factor: 3.252

8.  Adrenaline and phenylethanolamine-N-methyltransferase in rat medullary and anterior hypothalamic-preoptic nuclei.

Authors:  P M Beart; D Prosser; W J Louis
Journal:  J Neurochem       Date:  1979-10       Impact factor: 5.372

9.  Central dopaminergic neurons: effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acid.

Authors:  R H Roth; L C Murrin; J R Walters
Journal:  Eur J Pharmacol       Date:  1976-03       Impact factor: 4.432

10.  3,4-dihydroxyphenylacetic acid (DOPAC) and the rat mesolimbic dopaminergic pathway: drug effects and evidence for somatodendritic mechanisms.

Authors:  P M Beart; A L Gundlach
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739
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  3 in total

1.  Evidence for down-regulation of GABA receptors following long-term gamma-butyrolactone.

Authors:  G Gianutsos; P D Suzdak
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-11       Impact factor: 3.000

2.  Effect of haloperidol on glutamate decarboxylase activity in discrete brain areas of the rat.

Authors:  M Itoh
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

3.  Bicuculline insensitive effects of baclofen.

Authors:  L K Rägo; A M Zarkovsky
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000
  3 in total

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