Literature DB >> 4321473

Induction of liver acetaldehyde dehydrogenase: possible role in ethanol tolerance after exposure tobarbiturates.

G Redmond, G Cohen.   

Abstract

Mice were injected twice a day for 4 days with saline or phenobarbital or ethanol. Treatment with phenobarbital, but not ethanol, increased the amount of liver acetaldehyde dehydrogenase activity. More rapid removal of acetaldehyde, which is a toxic metabolic intermediate of ethanol, may contribute to the alcohol tolerance exhibited by persons who use barbiturates regularly.

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Year:  1971        PMID： 4321473     DOI： 10.1126/science.171.3969.387

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo.

Authors:  C J Eriksson; M Marselos; T Koivula
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

2.  Genetics and ontogeny of aldehyde dehydrogenase isozymes in th mouse: evidence for a locus controlling the inducibility of the liver microsomal isozyme.

Authors:  G P Timms; R S Holmes
Journal:  Biochem Genet       Date:  1981-12       Impact factor: 1.890

3.  Comparative simultaneous measurement of cerebrospinal fluid 5-hydroxyindoleacetic acid and blood serotonin levels in delirium tremens and clozapine-induced delirious reaction.

Authors:  C M Banki; M Vojnik
Journal:  J Neurol Neurosurg Psychiatry       Date:  1978-05       Impact factor: 10.154
  3 in total

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