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Literature DB >> 4320461

Mechanism of activation of catabolite-sensitive genes: a positive control system.

Abstract

Catabolite repression is defined as the inhibition of enzyme induction by glucose or related substances. In the bacterium E. coli, the effect of glucose appears to be due to a lowering of the cyclic AMP level. A DNA-directed cell-free system for beta-galactosidase synthesis has served as a model system for studying the mechanism of action of cyclic AMP. Previously, it was reported that in this system cyclic AMP is required for normal initiation of mRNA synthesis. A protein factor which acts in conjunction with the cyclic AMP has been partially purified. This protein factor has a high affinity for cyclic AMP. These and other results presented herein lead us to the conclusion that cyclic AMP and a protein factor called the catabolite gene activator protein are part of a positive control system for activating catabolite-sensitive genes.

Entities: Chemical Disease Gene Species

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Year: 1970 PMID： 4320461 PMCID： PMC286094 DOI： 10.1073/pnas.66.1.104

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

7 in total

1. Cyclic AMP as an antagonist of catabolite repression in Escherichia coli.

Authors: A Ullmann; J Monod
Journal: FEBS Lett Date: 1968-11 Impact factor: 4.124

2. ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI.

Authors: R S MAKMAN; E W SUTHERLAND
Journal: J Biol Chem Date: 1965-03 Impact factor: 5.157

3. Catabolite repression.

Authors: B MAGASANIK
Journal: Cold Spring Harb Symp Quant Biol Date: 1961

4. Regulation of beta-galactosidase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate.

Authors: R L Perlman; I Pastan
Journal: J Biol Chem Date: 1968-10-25 Impact factor: 5.157

5. The stimulatory effect of cyclic adenosine 3'5'-monophosphate on DNA-directed synthesis of beta-galactosidase in a cell-free system.

Authors: D A Chambers; G Zubay
Journal: Proc Natl Acad Sci U S A Date: 1969-05 Impact factor: 11.205

6. Catabolite sensitive site of the lac operon.

Authors: A E Silverstone; B Magasanik; W S Reznikoff; J H Miller; J R Beckwith
Journal: Nature Date: 1969-03-15 Impact factor: 49.962

7. Malate dehydrogenases. I. A survey of molecular size measured by gel filtration.

Authors: W H Murphey; G B Kitto; J Everse; N Kaplan
Journal: Biochemistry Date: 1967-02 Impact factor: 3.162

7 in total

174 in total

Review 1. Cyclic AMP in prokaryotes.

Authors: J L Botsford; J G Harman
Journal: Microbiol Rev Date: 1992-03

9. Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3':5' cyclic monophosphate.

Authors: M R Lakshmanan; C M Nepokroeff; J W Porter
Journal: Proc Natl Acad Sci U S A Date: 1972-12 Impact factor: 11.205

10. Positive control of endolysin synthesis in vitro by the gene N protein of phage lambda.

Authors: J Greenblatt
Journal: Proc Natl Acad Sci U S A Date: 1972-12 Impact factor: 11.205

Mechanism of activation of catabolite-sensitive genes: a positive control system.

1. Cyclic AMP as an antagonist of catabolite repression in Escherichia coli.

2. ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI.

3. Catabolite repression.

4. Regulation of beta-galactosidase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate.

5. The stimulatory effect of cyclic adenosine 3'5'-monophosphate on DNA-directed synthesis of beta-galactosidase in a cell-free system.

6. Catabolite sensitive site of the lac operon.

7. Malate dehydrogenases. I. A survey of molecular size measured by gel filtration.

Review 1. Cyclic AMP in prokaryotes.

2. Systematic mutagenesis of the Escherichia coli genome.

3. Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence.

4. Selective effects of fatty acids upon cell growth and metabolic regulation.

5. Novel protein kinase, AUT-PK 85, isolated from adrenocortical carcinoma: purification and characterization.

6. NMR study of the structural changes induced in the E. coli lac promoter by the specific binding of the CAP protein.

7. 3',5'-cyclic adenosine monophosphate-requiring mutants of Escherichia coli.

8. Purification and identification of the fruiting-inducing substances in Coprinus macrorhizus.

9. Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3':5' cyclic monophosphate.

10. Positive control of endolysin synthesis in vitro by the gene N protein of phage lambda.