Literature DB >> 4319388

Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma.

R J Lefkowitz, J Roth, I Pastan.   

Abstract

Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.

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Year:  1970        PMID： 4319388     DOI： 10.1126/science.170.3958.633

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Introduction of Robert J. Lefkowitz.

Authors:  Ralph Snyderman
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2.  A radioreceptor-assay for glucagon: binding of enteroglucagon to liver plasma membranes.

Authors:  J J Holst
Journal:  Diabetologia       Date:  1975-06       Impact factor: 10.122

3.  Inhibition of binding of corticotropin-(1-24)-tetracosapeptide (Synacthen) to membrane receptors of adrenal cortex by cortisol.

Authors:  A L Latner; D B Cook; K U Solanki
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4.  Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography.

Authors:  R J Lefkowitz; E Haber; D O'Hara
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

5.  Enzymic iodination. A probe for accessible surface proteins of normal and neoplastic lymphocytes.

Authors:  J J Marchalonis; R E Cone; V Santer
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

6.  Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

Authors:  J R Gavin; J Roth; D M Neville; P de Meyts; D N Buell
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

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8.  Development of a quantitative fluorescence-based ligand-binding assay.

Authors:  Conor J Breen; Mathilde Raverdeau; H Paul Voorheis
Journal:  Sci Rep       Date:  2016-05-10       Impact factor: 4.379

Review 9.  Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial-to-mesenchymal transition and oxidative stress.

Authors:  Haoxiao Zuo; Isabella Cattani-Cavalieri; Samuel Santos Valença; Nshunge Musheshe; Martina Schmidt
Journal:  Br J Pharmacol       Date:  2019-03-18       Impact factor: 8.739
  9 in total

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