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Literature DB >> 4315094

The effect of betamethasone on circadian and stress-induced pituitary-adrenocortical function in the rat.

Abstract

1. Both the circadian and stress-induced changes in plasma corticosterone concentration were abolished by the inclusion of betamethasone in the drinking water of rats.2. Adrenal sensitivity to exogenous corticotrophin (ACTH) was unimpaired by the betamethasone treatment.3. The normal circadian rhythm in plasma corticosterone returned within 1 day of withdrawal of the steroid, but the response to stress was normal only after 3 days.4. The possible significance of these observations is discussed.

Entities: Chemical Disease Species

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Year: 1970 PMID： 4315094 PMCID： PMC1702595 DOI： 10.1111/j.1476-5381.1970.tb09879.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

17 in total

1. Nychthemeral variations in plasma free corticosteroid levels of the rat.

Authors: R GUILLEMIN; W E DEAR; R A LIEBELT
Journal: Proc Soc Exp Biol Med Date: 1959-06

2. FAILURE TO INHIBIT CORTICOTROPHIN SECRETION BY EXPERIMENTALLY INDUCED INCREASES IN CORTICOID LEVELS.

Authors: P G SMELIK
Journal: Acta Endocrinol (Copenh) Date: 1963-09

3. Relation between blood level of corticoids and their inhibiting effect on the hypophyseal stress response.

Authors: P G SMELIK
Journal: Proc Soc Exp Biol Med Date: 1963-07

4. The estimation of small amounts of corticosterone in rat plasma.

Authors: N ZENKER; D E BERNSTEIN
Journal: J Biol Chem Date: 1958-04 Impact factor: 5.157

5. Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with cortisol.

Authors: J R Hodges; J Sadow
Journal: Br J Pharmacol Date: 1969-07 Impact factor: 8.739

6. Pituitary ACTH content in rats after partial or total interruption of neural afferents to the medial basal hypothalamus.

Authors: B Halász; J Vernikos-Danellis; R A Gorski
Journal: Endocrinology Date: 1967-10 Impact factor: 4.736

7. Sex difference in resting pituitary-adrenal function in the rat.

Authors: V Critchlow; R A Liebelt; M Bar-Sela; W Mountcastle; H S Lipscomb
Journal: Am J Physiol Date: 1963-11

8. Plasma corticosterone response to environmental stimulation: effects of duration of stimulation and the 24-hour adrenocortical rhythm.

Authors: R Ader; S B Friedman
Journal: Neuroendocrinology Date: 1968 Impact factor: 4.914

2. The effects of ether stress and betamethasone treatment on the concentrations of noradrenaline and dopamine in various regions of the rat brain.

Authors: S V Vellucci
Journal: Br J Pharmacol Date: 1977-08 Impact factor: 8.739

The effect of betamethasone on circadian and stress-induced pituitary-adrenocortical function in the rat.

1. Nychthemeral variations in plasma free corticosteroid levels of the rat.

2. FAILURE TO INHIBIT CORTICOTROPHIN SECRETION BY EXPERIMENTALLY INDUCED INCREASES IN CORTICOID LEVELS.

3. Relation between blood level of corticoids and their inhibiting effect on the hypophyseal stress response.

4. The estimation of small amounts of corticosterone in rat plasma.

5. Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with cortisol.

6. Pituitary ACTH content in rats after partial or total interruption of neural afferents to the medial basal hypothalamus.

7. Sex difference in resting pituitary-adrenal function in the rat.

8. Plasma corticosterone response to environmental stimulation: effects of duration of stimulation and the 24-hour adrenocortical rhythm.

9. Effects of intracerebral dexamethasone on pituitary-adrenal function in female rats.

10. Effects of diurnal variation in plasma corticosterone levels on adrenocortical response to stress.

1. The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone.

2. The effects of ether stress and betamethasone treatment on the concentrations of noradrenaline and dopamine in various regions of the rat brain.

3. Diurnal variation in the response to ACTH.

4. Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone.

5. Recovery of hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with betamethasone.

6. Suppression of adrenocorticotrophic activity in the ascorbic acid deficient guinea-pig.

7. Effects of stress and betamethasone on the production of corticosterone by the rat adrenal gland in vitro.

8. Effect of prolonged treatment with tetracosactrin on hypothalamo-pituitary-adrenal function in the rat.