Literature DB >> 4329984

Suppression of adrenocorticotrophic activity in the ascorbic acid deficient guinea-pig.

J R Hodges, R T Hotston.   

Abstract

1. Adrenocortical hyperactivity caused by a marked increase in circulating corticotrophin occurred in guinea-pigs on a diet deficient in ascorbic acid.2. Betamethasone prevented the rise in the blood ACTH concentration in scorbutic animals and also the increased steroid production per gramme adrenal tissue in vitro. It diminished the adrenal hypertrophy and partially suppressed the rise in plasma cortisol.3. Ninety minutes after the injection of ascorbic acid corticotrophin could no longer be detected in the plasma of scorbutic animals.4. Neither the survival time nor the weight loss was affected by betamethasone treatment.

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Year:  1971        PMID： 4329984      PMCID： PMC1665767          DOI： 10.1111/j.1476-5381.1971.tb07143.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  18 in total

1.  The effect of corticotropin on the formation of corticosteroids in vitro.

Authors:  R F BAKKER; D de WIED
Journal:  Can J Biochem Physiol       Date:  1961-01

2.  Corticotrophin release in the cortisol-treated rat.

Authors:  J R HODGES; M T JONES
Journal:  J Physiol       Date:  1962-10       Impact factor: 5.182

3.  Pituitary and blood corticotrophin changes in adrenalectomized rats maintained on physiological doses of corticosteroids.

Authors:  J R HODGES; J VERNIKOS-DANELLIS
Journal:  Acta Endocrinol (Copenh)       Date:  1962-01

4.  Circulating corticotrophin in normal and adrenalectomized rats after stress.

Authors:  J R HODGES; J VERNIKOS
Journal:  Acta Endocrinol (Copenh)       Date:  1959-02

5.  The effect of cortisone in guinea-pigs.

Authors:  B E CLAYTON
Journal:  J Endocrinol       Date:  1954-07       Impact factor: 4.286

6.  Maintenance of blood 17-hydroxycorticosteroids following ascorbic acid treatment.

Authors:  H BACCHUS
Journal:  Endocrinology       Date:  1954-04       Impact factor: 4.736

7.  Potentiating effect of ascorbic acid on cortisone-induced gluconeogenesis.

Authors:  H BACCHUS; M H HEIFFER; N ALTSZULER
Journal:  Proc Soc Exp Biol Med       Date:  1952-04

8.  Some effects of cortisone on vitamin C-deficient guinea pigs.

Authors:  E H HERRICK; E R MEAD; B W EGERTON; J S HUGHES
Journal:  Endocrinology       Date:  1952-02       Impact factor: 4.736

9.  Effect of cortisone and adrenocorticotrophic hormone (ACTH) on experimental scurvy in the guinea pig.

Authors:  G A HYMAN; C RAGAN; J C TURNER
Journal:  Proc Soc Exp Biol Med       Date:  1950-11

10.  Ascorbic acid deficiency and pituitary adrenocortical activity in the guinea-pig.

Authors:  J R Hodges; R T Hotston
Journal:  Br J Pharmacol       Date:  1970-12       Impact factor: 8.739
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  2 in total

1.  Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone.

Authors:  J C Buckingham; J R Hodges
Journal:  Br J Pharmacol       Date:  1976-02       Impact factor: 8.739

2.  Vitamin C Transporters, Recycling and the Bystander Effect in the Nervous System: SVCT2 versus Gluts.

Authors:  Francisco Nualart; Lauren Mack; Andrea García; Pedro Cisternas; Ernesto R Bongarzone; Marjet Heitzer; Nery Jara; Fernando Martínez; Luciano Ferrada; Francisca Espinoza; Victor Baeza; Katterine Salazar
Journal:  J Stem Cell Res Ther       Date:  2014-05-19
  2 in total

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