Literature DB >> 43147

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver.

S K Joseph, N M Bradford, J D McGivan.   

Abstract

Glutamine synthetase activity in a cytosol extract of liver was inhibited non-competitively by Mn2+ ions. The apparent Ki for Mn2" in the presence of phosphate was 8 micro M. Inhibition of glutamine synthetase by intracellular Mn2+ may contribute to the very low rates of glutamine synthesis observed in perfused liver and isolated hepatocytes.

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Year:  1979        PMID： 43147      PMCID： PMC1161787          DOI： 10.1042/bj1840477

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Characteristics of aspartate deamination by the puring nucleotide cycle in the cytosol fraction of rat liver.

Authors:  K M Moss; J D McGivan
Journal:  Biochem J       Date:  1975-08       Impact factor: 3.857

2.  Effects of manganese on the activity of glycolytic and gluconeogenic enzymes in the perfused rat liver.

Authors:  J M Wimhurst; K L Manchester
Journal:  FEBS Lett       Date:  1973-01-15       Impact factor: 4.124

3.  Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate.

Authors:  S S Tate; F Y Leu; A Meister
Journal:  J Biol Chem       Date:  1972-09-10       Impact factor: 5.157

4.  Binding of adenosine triphosphate and adenosine diphosphate by glutamine synthetase.

Authors:  V P Wellner; A Meister
Journal:  Biochemistry       Date:  1966-03       Impact factor: 3.162

5.  Control of glutamine synthesis in rat liver.

Authors:  P Lund
Journal:  Biochem J       Date:  1971-09       Impact factor: 3.857

6.  Regulation of rat liver glutamine synthetase: activation by alpha-ketoglutarate and inhibition by glycine, alanine, and carbamyl phosphate.

Authors:  S S Tate; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

7.  The effect of ammonium chloride and glucagon on the metabolism of glutamine in isolated liver cells from starved rats.

Authors:  S K Joseph; J D McGivan
Journal:  Biochim Biophys Acta       Date:  1978-09-21

Review 8.  Metabolic aspects of acid-base change.

Authors:  W D Lotspeich
Journal:  Science       Date:  1967-03-03       Impact factor: 47.728
  8 in total
  3 in total

1.  Is hydrogen peroxide involved in the benzyl viologen-mediated in-vivo inactivation of rat liver glutamine synthetase?

Authors:  F J Muriana; V Ruiz-Gutierrez; A M Relimpio
Journal:  Int J Exp Pathol       Date:  1993-04       Impact factor: 1.925

2.  Effects of Mn2+ and Mg2+ on assimilation of NO3- and NH4+ by soil microorganisms.

Authors:  G W McCarty; J M Bremner
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

Review 3.  The role of metals in carcinogenesis: biochemistry and metabolism.

Authors:  K W Jennette
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031
  3 in total

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