Literature DB >> 1180919

Characteristics of aspartate deamination by the puring nucleotide cycle in the cytosol fraction of rat liver.

K M Moss, J D McGivan.   

Abstract

1. The component reactions of the puring nucleotide cycle were studied in cytosol extracts of rat liver. 2. AMP deaminase was strongly activated by ATP and analogues of ATP. 3. IMP was converted into ATP by a system requiring the presence of aspartate, GTP and a nucleoside triphosphate-regenerating system. 4. Under appropriate conditions, NH3 was produced from aspartate. 5. From the rates at which these reactions occur it is concluded that the purine nucleotide cycle may have sufficient activity to be a major pathway of amino acid deamination in liver.

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Year:  1975        PMID： 1180919      PMCID： PMC1165736          DOI： 10.1042/bj1500275

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  On the metabolic function of glutamate dehydrogenase in rat liver.

Authors:  J D McGivan; J B Chappell
Journal:  FEBS Lett       Date:  1975-03-15       Impact factor: 4.124

2.  An improved method for the colorimetric determination of phosphate.

Authors:  I Berenblum; E Chain
Journal:  Biochem J       Date:  1938-02       Impact factor: 3.857

3.  Purification of adenylosuccinate synthetase from rabbit skeletal muscle.

Authors:  K M Muirhead; S H Bishop
Journal:  J Biol Chem       Date:  1974-01-25       Impact factor: 5.157

4.  The cause of hepatic accumulation of fructose 1-phosphate on fructose loading.

Authors:  H F Woods; L V Eggleston; H A Krebs
Journal:  Biochem J       Date:  1970-09       Impact factor: 3.857

5.  Purification and properties of rat liver AMP deaminase.

Authors:  L D Smith; D E Kizer
Journal:  Biochim Biophys Acta       Date:  1969-11-04

6.  Specific protection of folate reductase against chemical and proteolytic inactivation.

Authors:  M T Hakala; E M Suolinna
Journal:  Mol Pharmacol       Date:  1966-09       Impact factor: 4.436

7.  The effects L-leucine on the synthesis of urea, glutamate and glutamine by isolated rat liver cells.

Authors:  J M Mourão; J D McGivan; J B Chappell
Journal:  Biochem J       Date:  1975-02       Impact factor: 3.857

8.  Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.

Authors:  D H Williamson; O Lopes-Vieira; B Walker
Journal:  Biochem J       Date:  1967-08       Impact factor: 3.857

9.  Quantitative characteristics of glutamate transport in rat liver mitochondria.

Authors:  N M Bradford; J D McGivan
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

10.  Adaptive changes in the capacity of systems used for the synthesis of citrulline in rat liver mitochondria in response to high- and-low-protein diets.

Authors:  J D McGivan; N M Bradford; J B Chappell
Journal:  Biochem J       Date:  1974-08       Impact factor: 3.857
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  3 in total

1.  Adenosine triphosphate-activated adenylate deaminase from marine invertebrate animals. Properties of the enzyme from lugworm (Arenicola cristata) body-wall muscle.

Authors:  K L Gibbs; S H Bishop
Journal:  Biochem J       Date:  1977-06-01       Impact factor: 3.857

2.  Deficiency of AMP deaminase in erythrocytes.

Authors:  N Ogasawara; H Goto; Y Yamada; I Nishigaki; T Itoh; I Hasegawa; K S Park
Journal:  Hum Genet       Date:  1987-01       Impact factor: 4.132

3.  Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver.

Authors:  S K Joseph; N M Bradford; J D McGivan
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857
  3 in total

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