Literature DB >> 4302187

Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro.

P De Somer, E De Clercq, A Billiau, E Schonne, M Claesen.   

Abstract

Polyacrylic acid (PAA) and polymethacrylic acid (PMAA) were investigated for their antiviral properties in tissue culture. Compared to other related polyanions, as dextran sulfate, polystyrene sulfonate, polyvinyl sulfate, and polyphloroglucinol phosphate, PAA and PMAA were found to be significantly more antivirally active and less cytotoxic. PMAA added 24 hr prior to virus inoculation inhibited viral growth most efficiently but it was still effective when added 3 hr after infection. Neither a direct irreversible action on the virus nor inhibition of virus penetration into the cell could explain the antiviral activity of PMAA. PMAA inhibited the adsorption of the virus to the host cell and suppressed the one-cycle viral synthesis in tissue cultures inoculated with infectious RNA.

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Year:  1968        PMID： 4302187      PMCID： PMC375707     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  STARCH GEL AS AN OVERLAY FOR THE PLAQUE ASSAY OF ANIMAL VIRUSES.

Authors:  E DEMAEYER; E SCHONNE
Journal:  Virology       Date:  1964-09       Impact factor: 3.616

2.  Inhibition of infectious and hemagglutinating properties of type 2 dengue virus by aqueous Agar extracts.

Authors:  I T SCHULZE; R W SCHLESINGER
Journal:  Virology       Date:  1963-01       Impact factor: 3.616

3.  Ethylene maleic anhydride copolymers as viral inhibitors.

Authors:  E T FELTZ; W REGELSON
Journal:  Nature       Date:  1962-11-17       Impact factor: 49.962

4.  Inhibitory effect of synthetic lysine polypeptides on growth of influenza virus in embryonated eggs.

Authors:  J R RUBINI; A F RASMUSSEN; M A STAHMANN
Journal:  Proc Soc Exp Biol Med       Date:  1951-04

5.  [Enhancement, by addition of diethylaminoethyl-dextran, of the infectivity of ribonucleic acid from foot-and-mouth disease virus].

Authors:  M T Fayet
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1967-01-30

6.  Infectious poliovirus RNA: a sensitive method of assay.

Authors:  A Vaheri; J S Pagano
Journal:  Virology       Date:  1965-11       Impact factor: 3.616

7.  Inhibitory effect of heparin on Rous sarcoma virus.

Authors:  J J Solomon; K A Glatt; W Okazaki
Journal:  J Bacteriol       Date:  1966-12       Impact factor: 3.490

8.  Inhibitory effect of heparin on herpes simplex virus.

Authors:  A J Nahmias; S Kibrick
Journal:  J Bacteriol       Date:  1964-05       Impact factor: 3.490

9.  Enhancement of infectivity of poliovirus RNA with diethylaminoethyl-dextran (DEAE-D).

Authors:  J S Pagano; A Vaheri
Journal:  Arch Gesamte Virusforsch       Date:  1965

10.  Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.

Authors:  P De Somer; E De Clercq; A Billiau; E Schonne; M Claesen
Journal:  J Virol       Date:  1968-09       Impact factor: 5.103
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  19 in total

1.  Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae.

Authors:  H Nakashima; Y Kido; N Kobayashi; Y Motoki; M Neushul; N Yamamoto
Journal:  Antimicrob Agents Chemother       Date:  1987-10       Impact factor: 5.191

2.  Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus.

Authors:  M Baba; R Snoeck; R Pauwels; E de Clercq
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

3.  Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs.

Authors:  Tejabhiram Yadavalli; Sudipta Mallick; Pratikkumar Patel; Raghuram Koganti; Deepak Shukla; Abhijit A Date
Journal:  ACS Infect Dis       Date:  2020-10-20       Impact factor: 5.084

Review 4.  Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  2001-04       Impact factor: 26.132

5.  Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity.

Authors:  S Ormai; M Palkovits
Journal:  Blut       Date:  1975-10

6.  Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.

Authors:  P De Somer; E De Clercq; A Billiau; E Schonne; M Claesen
Journal:  J Virol       Date:  1968-09       Impact factor: 5.103

7.  Protection of rabbits against local vaccinia virus infection by Brucella abortus and polyacrylic acid in the absence of systemic interferon production.

Authors:  E De Clercq; P De Somer
Journal:  Infect Immun       Date:  1973-10       Impact factor: 3.441

8.  Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus.

Authors:  E De Clercq; P De Somer
Journal:  Appl Microbiol       Date:  1968-09

9.  Antiviral activity of carbopol, a cross-linked polycarboxylate.

Authors:  E de Clercq; M Luczak
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

10.  Polyacetal carboxylic acids: a new group of antiviral polyanions.

Authors:  P Claes; A Billiau; E De Clercq; J Desmyter; E Schonne; H Vanderhaeghe; P De Somer
Journal:  J Virol       Date:  1970-03       Impact factor: 5.103
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