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Literature DB >> 187146

Antiviral activity of carbopol, a cross-linked polycarboxylate.

Abstract

Carbopol, a polymer of acrylic acid cross-linked with allylsucrose, was found to impart resistance to virus infection in mice which received an intraperitoneal injection of the polycarboxylate 1 or 4 days before either intravenous vaccinia virus challenge or intranasal herpes simplex virus challenge. An interferon-like substance was detected in the blood stream 20-40 hours after the intraperitoneal injection of carbopol. The antiviral activity of this cross-linked polycarboxylate could be due to activation of peritoneal macrophages and/or interferon production.

Entities: Chemical Disease Species

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Year: 1976 PMID： 187146 DOI： 10.1007/bf01317874

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

23 in total

3. Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs.

Authors: Tejabhiram Yadavalli; Sudipta Mallick; Pratikkumar Patel; Raghuram Koganti; Deepak Shukla; Abhijit A Date
Journal: ACS Infect Dis Date: 2020-10-20 Impact factor: 5.084

3 in total

Antiviral activity of carbopol, a cross-linked polycarboxylate.

1. Inhibition and enhancement of Friend leukemia virus by pyran copolymer.

2. Interferon production by mouse peritoneal cells.

3. A more sensitive assay system for the detection of RNA-dependent DNA polymerase in oncogenic RNA viruses.

4. Antitumor activity of silica gel PF 254 eluate.

5. Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers.

6. Prolonged antiviral protection by interferon inducers.

7. Production by stimulated macrophages of factors depressing lymphocyte transformation.

8. Sources of leukocytic endogenous mediator in the rat.

9. Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.

10. Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid.

1. Polysaccharides as antiviral agents: antiviral activity of carrageenan.

2. Resistance to vaginal or systemic infection with herpes simplex virus type 2.

3. Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs.