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Literature DB >> 4299128

Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol.

Abstract

1. The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was detected and isolated after microsomal incubations of the diols. 3. The accompanying reduction of NAD(+) was followed spectrophotometrically. 4. The optimum pH for the microsomal reaction was 9.4 for the oxidation of the cis-diol and 9.8 for that of the trans-diol. 5. p-Chloromercuribenzoate and 2,4-dichlorophenol inhibited the reaction. 6. Possible mechanisms for the microsomal ring-fission, involving 1,8-naphthalic aldehyde, are discussed.

Entities: Chemical Species

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Year: 1968 PMID： 4299128 PMCID： PMC1198853 DOI： 10.1042/bj1080577

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

6 in total

1. Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol.

Authors: P K AYENGAR; O HAYAISHI; M NAKAJIMA; I TOMIDA
Journal: Biochim Biophys Acta Date: 1959-05

2. Biochemical studies of toxic agents. 13. The metabolism of acenaphthylene.

Authors: R P HOPKINS; C J BROOKS; L YOUNG
Journal: Biochem J Date: 1962-03 Impact factor: 3.857

3. Enzymatic metabolism of drugs and other foreign compounds.

Authors: B B BRODIE; J R GILLETTE; B N LA DU
Journal: Annu Rev Biochem Date: 1958 Impact factor: 23.643

4. Tissue fractionation studies. VII. Release of bound hydrolases by means of triton X-100.

Authors: C DE DUVE; R WATTIAUX
Journal: Biochem J Date: 1956-08 Impact factor: 3.857

5. Biochemical studies of toxic agents. Metabolic ring-fission of cis- and trans-acenaphthene-1,2-diol.

Authors: R P Hopkins; L Young
Journal: Biochem J Date: 1966-01 Impact factor: 3.857

6. [On the chemistry of benzene glycol. VI. Metabolism of benzene glycols and muconic dialdehydes].

Authors: I TOMIDA; M NAKAJIMA
Journal: Hoppe Seylers Z Physiol Chem Date: 1960-05-31

6 in total

5 in total

Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol.

1. Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol.

2. Biochemical studies of toxic agents. 13. The metabolism of acenaphthylene.

3. Enzymatic metabolism of drugs and other foreign compounds.

4. Tissue fractionation studies. VII. Release of bound hydrolases by means of triton X-100.

5. Biochemical studies of toxic agents. Metabolic ring-fission of cis- and trans-acenaphthene-1,2-diol.

6. [On the chemistry of benzene glycol. VI. Metabolism of benzene glycols and muconic dialdehydes].

1. Investigation of the metabolic oxidation of acenaphthen-1-ol.

2. Microsomal dehydrogenation of cis- and trans-acenaphthene-1,2-diol to acenaphthenequinone.

3. Bacterial oxidation of the polycyclic aromatic hydrocarbons acenaphthene and acenaphthylene.

4. Degradation of diarylethane structures by Pseudomonas fluorescens biovar I.

5. Fungal metabolism of acenaphthene by Cunninghamella elegans.