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Literature DB >> 4291958

Production of high-titer antibody in serum and ascitic fluid of hamsters for a variety of virus-induced tumor antigens.

Abstract

Methods not involving the use of viable tumors were developed for production of high-titer antibodies. The methods involved use of tumor homogenates. Homogenates from all tumor lines tested contained the characteristic tumor antigen. Attempts to isolate virus failed, and virus antigens could not be demonstrated. Immunization with tumor homogenates, in Freund's complete adjuvant, resulted in high antibody levels. None of the animals so immunized developed tumors.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1967 PMID： 4291958 PMCID： PMC546999 DOI： 10.1128/am.15.3.657-660.1967

Source DB: PubMed Journal: Appl Microbiol ISSN： 0003-6919

12 in total

1. EXPRESSION OF POLYOMA-INDUCED CELLULAR ANTIGEN(S) IN HYBRID CELLS.

Authors: V DEFENDI; B EPHRUSSI; H KOPROWSKI
Journal: Nature Date: 1964-08-01 Impact factor: 49.962

2. AN AVIAN LEUCOSIS GROUP-SPECIFIC COMPLEMENT FIXATION REACTION. APPLICATION FOR THE DETECTION AND ASSAY OF NON-CYTOPATHOGENIC LEUCOSIS VIRUSES.

Authors: P S SARMA; H C TURNER; R J HUEBNER
Journal: Virology Date: 1964-07 Impact factor: 3.616

3. SPECIFIC COMPLEMENT-FIXING VIRAL ANTIGENS IN HAMSTER AND GUINEA PIG TUMORS INDUCED BY THE SCHMIDT-RUPPIN STRAIN OF AVIAN SARCOMA.

Authors: R J HUEBNER; D ARMSTRONG; M OKUYAN; P S SARMA; H C TURNER
Journal: Proc Natl Acad Sci U S A Date: 1964-05 Impact factor: 11.205

9. Tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and "neoantigens" with those produced by adenovirus type 7 tumors.

Authors: R J Huebner; M J Casey; R M Chanock; K Schell
Journal: Proc Natl Acad Sci U S A Date: 1965-08 Impact factor: 11.205

Production of high-titer antibody in serum and ascitic fluid of hamsters for a variety of virus-induced tumor antigens.

1. EXPRESSION OF POLYOMA-INDUCED CELLULAR ANTIGEN(S) IN HYBRID CELLS.

2. AN AVIAN LEUCOSIS GROUP-SPECIFIC COMPLEMENT FIXATION REACTION. APPLICATION FOR THE DETECTION AND ASSAY OF NON-CYTOPATHOGENIC LEUCOSIS VIRUSES.

3. SPECIFIC COMPLEMENT-FIXING VIRAL ANTIGENS IN HAMSTER AND GUINEA PIG TUMORS INDUCED BY THE SCHMIDT-RUPPIN STRAIN OF AVIAN SARCOMA.

4. SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORS.

5. SPECIFIC COMPLEMENT-FIXING TUMOR ANTIGENS IN HUMAN CELLS MORPHOLOGICALLY TRANSFORMED BY SV40 VIRUS.

6. SPECIFIC COMPLEMENT-FIXING ANTIGENS IN POLYOMA TUMORS AND TRANSFORMED CELLS.

7. Application of a microtechnique to viral serological investigations.

8. Hamster ascitic fluids containing complement-fixing antibody against virus-induced tumor antigens.

9. Tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and "neoantigens" with those produced by adenovirus type 7 tumors.

10. IMMUNOFLUORESCENT STUDIES OF ADENOVIRUS 12 TUMORS AND OF CELLS TRANSFORMED OR INFECTED BY ADENOVIRUSES.

1. T antigens of bovine and canine adenoviruses demonstrated by immunofluorescence.

2. Serological studies of the T and tumor antigens of the oncogenic simian adenoviruses.

3. Simian virus 40-induced T and tumor antigens.