Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae.

Literature DB >> 4279906

Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae.

Abstract

A cell-free protein synthesizing system was used to study the mechanism of resistance to streptomycin (Str) and spectinomycin (Spc) in laboratory mutants and clinical isolates of Neisseria gonorrhoeae. The 70S ribosomes from sensitive strains were sensitive to the effects of Str and Spc on synthesis directed by several synthetic polynucleotide messengers, whereas 70S ribosomes from resistant strains were resistant to these same effects. In each case, the alteration was localized to the 30S ribosomal subunit by studying antibiotic sensitivities of hybrid 70S ribosomes formed by combining subunits from sensitive and resistant strains. No evidence was found for streptomycin- or spectinomycin-inactivating enzymes.

Entities: Chemical Species

Mesh：

Substances：

Year: 1974 PMID： 4279906 PMCID： PMC245914 DOI： 10.1128/jb.120.3.1293-1299.1974

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

19 in total

1. DISAPPEARANCE OF OXYTETRACYCLINE ACCUMULATION IN THE CELLS OF MULTIPLE DRUG-RESISTANT ESCHERICHIA COLI.

Authors: K IZAKI; K ARIMA
Journal: Nature Date: 1963-10-26 Impact factor: 49.962

2. Bacterial ribosome.

Authors: M Nomura
Journal: Bacteriol Rev Date: 1970-09

Review 3. Mechanisms of antibiotic resistance in bacteria.

Authors: R Benveniste; J Davies
Journal: Annu Rev Biochem Date: 1973 Impact factor: 23.643

4. Ribosomes from Escherichia coli merodiplods heterozygous for resistance to streptomycin and to spectinomycin.

Authors: P F Sparling; J Modolell; Y Takeda; B D Davis
Journal: J Mol Biol Date: 1968-11-14 Impact factor: 5.469

5. Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli.

Authors: P Anderson; J Davies; B D Davis
Journal: J Mol Biol Date: 1967-10-14 Impact factor: 5.469

Review 6. The genetics of bacterial ribosomes.

Authors: J Davies; M Nomura
Journal: Annu Rev Genet Date: 1972 Impact factor: 16.830

7. Antibiotic inhibitors of the bacterial ribosome.

Authors: B Weisblum; J Davies
Journal: Bacteriol Rev Date: 1968-12

8. Selective filtration of antibiotics through collodion membranes.

Authors: M Barza; M G Bergeron; J Brusch; L Weinstein
Journal: Antimicrob Agents Chemother Date: 1973-09 Impact factor: 5.191

9. Ribosomal protein conferring sensitivity to the antibiotic spectinomycin in Escherichia coli.

Authors: A Bollen; J Davies; M Ozaki; S Mizushima
Journal: Science Date: 1968-07-04 Impact factor: 47.728

10. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.

Authors: D S KELLOGG; W L PEACOCK; W E DEACON; L BROWN; D I PIRKLE
Journal: J Bacteriol Date: 1963-06 Impact factor: 3.490

20 in total

Review 1. Antimicrobial agents and gonorrhoea: therapeutic choice, resistance and susceptibility testing.

Authors: C A Ison
Journal: Genitourin Med Date: 1996-08

Review 2. Genetic loci and linkage associations in Neisseria gonorrhoeae and Neisseria meningitidis.

Authors: S E West; V L Clark
Journal: Clin Microbiol Rev Date: 1989-04 Impact factor: 26.132

3. Neisseria gonorrhoeae Evades Calprotectin-Mediated Nutritional Immunity and Survives Neutrophil Extracellular Traps by Production of TdfH.

Authors: Sophonie Jean; Richard A Juneau; Alison K Criss; Cynthia N Cornelissen
Journal: Infect Immun Date: 2016-09-19 Impact factor: 3.441

Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae.

1. DISAPPEARANCE OF OXYTETRACYCLINE ACCUMULATION IN THE CELLS OF MULTIPLE DRUG-RESISTANT ESCHERICHIA COLI.

2. Bacterial ribosome.

Review 3. Mechanisms of antibiotic resistance in bacteria.

4. Ribosomes from Escherichia coli merodiplods heterozygous for resistance to streptomycin and to spectinomycin.

5. Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli.

Review 6. The genetics of bacterial ribosomes.

7. Antibiotic inhibitors of the bacterial ribosome.

8. Selective filtration of antibiotics through collodion membranes.

9. Ribosomal protein conferring sensitivity to the antibiotic spectinomycin in Escherichia coli.

10. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.

Review 1. Antimicrobial agents and gonorrhoea: therapeutic choice, resistance and susceptibility testing.

Review 2. Genetic loci and linkage associations in Neisseria gonorrhoeae and Neisseria meningitidis.

3. Neisseria gonorrhoeae Evades Calprotectin-Mediated Nutritional Immunity and Survives Neutrophil Extracellular Traps by Production of TdfH.

4. In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.

5. Plasmid-mediated chromosomal gene transfer in Neisseria gonorrhoeae.

6. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae.

7. Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations.

8. Absence of penicillin-degrading enzymes in penicillin-resistant strains of Neisseria gonorrhoeae.

9. Spectinomycin resistant gonococci.

Review 10. Versatility of aminoglycosides and prospects for their future.