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Literature DB >> 4272702

Myosin ATP hydrolysis: a mechanism involving a magnesium chelate complex.

Abstract

It is suggested that under physiological conditions (> 1 mM Mg(2+)) MgATP binds to myosin to form a chelate involving the two reactive sulfhydryl sites (SH(1) and SH(2)). The stability of the chelate structure results in marked inhibition of the myosin ATPase in the presence of millimolar magnesium ion. The inhibitory effect of magnesium ion can be eliminated chemically by blocking either the SH(1) or SH(2) site since this precludes formation of the chelate. In muscle, actin apparently behaves in a similar fashion in that its interaction with myosin causes a disruption of the chelate structure.

Entities: Chemical Gene

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Year: 1973 PMID： 4272702 PMCID： PMC427330 DOI： 10.1073/pnas.70.12.3793

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. ON THE ACTIVATION OF MYOSIN ATPASE BY EDTA.

Authors: A MUEHLRAD; F FABIAN; N A BIRO
Journal: Biochim Biophys Acta Date: 1964-07-08

2. On the role of calcium in the activity of adenosine 5'-triphosphate hydrolysis by actomyosin.

Authors: A WEBER
Journal: J Biol Chem Date: 1959-10 Impact factor: 5.157

3. Similar effects on enzymic activity due to chemical modification of either of two sulfhydryl groups of myosin.

Authors: J C Seidel
Journal: Biochim Biophys Acta Date: 1969-05

4. Sulfhydryl groups involved in the active site of myosin A adenosine triphosphatase. I. Specific blocking of the SH group responsible for the inhibitory phase in "B phasic response" of the catalytic activity.

Authors: M Yamaguchi; T Sekine
Journal: J Biochem Date: 1966-01 Impact factor: 3.387

5. Thiolysis of dinitrophenylated myosin with restoration of adenosine triphosphatase activity.

Authors: G Bailin; M Bárány
Journal: J Biol Chem Date: 1972-12-10 Impact factor: 5.157

6. Interaction of SH 1 -blocked HMM with actin and ATP.

Authors: R Silverman; E Eisenberg; W W Kielley
Journal: Nat New Biol Date: 1972-12-13

7. Kinetics and substrate binding of myosin adenosine triphosphatase.

Authors: B Kiely; A Martonosi
Journal: J Biol Chem Date: 1968-05-10 Impact factor: 5.157

8. The effects of monovalent and divalent cations on the ATPase activity of myosin.

Authors: J C Seidel
Journal: Biochim Biophys Acta Date: 1969-10-21

Review 9. The molecular basis of muscle contraction.

Authors: M Young
Journal: Annu Rev Biochem Date: 1969 Impact factor: 23.643

10. A simple procedure for the preparation of tropomyosin-free F-actin.

Authors: G Bailin; M Bárány
Journal: J Mechanochem Cell Motil Date: 1972-12

7 in total

1. Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1.

Authors: J A Wells; R G Yount
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

2. Unusual features of the Ca2+-ATPase activity of myosin from fast skeletal muscle of the frog: effect of actin and SH1 thiol group modification.

Authors: H Strzelecka-Gołaszewska; B Pliszka; M Mossakowska; U Piwowar
Journal: J Muscle Res Cell Motil Date: 1983-04 Impact factor: 2.698

3. Formation of ATP-insensitive weakly-binding crossbridges in single rabbit psoas fibers by treatment with phenylmaleimide or para-phenylenedimaleimide.

Authors: V A Barnett; A Ehrlich; M Schoenberg
Journal: Biophys J Date: 1992-02 Impact factor: 4.033