Literature DB >> 427007

Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals.

C P Dawes, M J Kendall, P G Welling.   

Abstract

1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow-release tablets. 3 Slow-release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma-drug profiles in fasted and nonfasted individuals.

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Year:  1979        PMID： 427007      PMCID： PMC1429485          DOI： 10.1111/j.1365-2125.1979.tb00936.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  10 in total

1.  Simplified method for the determination of oxprenolol and other beta-receptor-blocking agents in biological fluids by gas-liquid chromatography.

Authors:  P H Degen; W Riess
Journal:  J Chromatogr       Date:  1976-06-09

2.  Pharmacokinetics of oxprenolol in normal subjects.

Authors:  W D Mason; N Winer
Journal:  Clin Pharmacol Ther       Date:  1976-10       Impact factor: 6.875

3.  Comparison of antibacterial activity in the sera of subjects ingesting propionyl erythromycin lauryl sulfate and erythromycin ethyl carbonate.

Authors:  R S GRIFFITH
Journal:  Antibiotic Med Clin Ther (New York)       Date:  1960-05

4.  An evaluation of erythromycin stearate and propionyl erythromycin in normal and hospitalized subjects.

Authors:  W E CLAPPER; M MOSTYN; G H MEADE
Journal:  Antibiotic Med Clin Ther (New York)       Date:  1960-02

5.  Absorption following oral administration of erythromycin.

Authors:  J W SMITH; R W DYKE; R S GRIFFITH
Journal:  J Am Med Assoc       Date:  1953-03-07

6.  Enhancement of the bioavailability of propranolol and metoprolol by food.

Authors:  A Melander; K Danielson; B Scherstén; E Wåhlin
Journal:  Clin Pharmacol Ther       Date:  1977-07       Impact factor: 6.875

7.  Plasma metoprolol concentrations in young, old and hypertensive subjects.

Authors:  M J Kendall; D Brown; R A Yates
Journal:  Br J Clin Pharmacol       Date:  1977-08       Impact factor: 4.335

Review 8.  Influence of food and diet on gastrointestinal drug absorption: a review.

Authors:  P G Welling
Journal:  J Pharmacokinet Biopharm       Date:  1977-08

9.  Plasma propranolol levels in adults with observations in four children.

Authors:  D G Shand; E M Nuckolls; J A Oates
Journal:  Clin Pharmacol Ther       Date:  1970 Jan-Feb       Impact factor: 6.875

10.  A comparison of slow release with conventional oxprenolol: plasma concentrations and clinical effects.

Authors:  M J West; M J Kendall; M Mitchard; E B Faragher
Journal:  Br J Clin Pharmacol       Date:  1976-06       Impact factor: 4.335
  10 in total
  7 in total

1.  Jejunal and ileal absorption of oxprenolol in man: influence of nutrients and digestive secretions on jejunal absorption and systemic availability.

Authors:  J Godbillon; N Vidon; R Palma; A Pfeiffer; C Franchisseur; M Bovet; G Gosset; J J Bernier; J Hirtz
Journal:  Br J Clin Pharmacol       Date:  1987-09       Impact factor: 4.335

2.  Variability of beta-blocker pharmacokinetics in young volunteers.

Authors:  D B Jack; C P Quarterman; R Zaman; M J Kendall
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

Review 3.  Interactions affecting drug absorption.

Authors:  P G Welling
Journal:  Clin Pharmacokinet       Date:  1984 Sep-Oct       Impact factor: 6.447

4.  Influence of food intake on plasma oxprenolol concentrations following oral administration of conventional and Oros preparations.

Authors:  V A John; S E Smith
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

5.  Comparison of the activity and plasma levels of oxprenolol, slow release oxprenolol, long acting propranolol and sotalol.

Authors:  W J Leahey; J D Neill; M P Varma; R G Shanks
Journal:  Eur J Clin Pharmacol       Date:  1980-06       Impact factor: 2.953

6.  Effect of food on the absorption of hydralazine in man.

Authors:  R J Walden; R Hernandez; D Witts; B R Graham; B N Prichard
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

7.  Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.

Authors:  Josée Bouchard; Greene Shepherd; Robert S Hoffman; Sophie Gosselin; Darren M Roberts; Yi Li; Thomas D Nolin; Valéry Lavergne; Marc Ghannoum
Journal:  Crit Care       Date:  2021-06-10       Impact factor: 9.097
  7 in total

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