Literature DB >> 4262344

Acrosomal proteinase and proteinase inhibitor of human spermatozoa.

L J Zaneveld, B M Dragoje, G F Schumacher.   

Abstract

The acrosomal proteinase of human spermatozoa was characterized and differs from other human proteinases. The enzyme has optimal activity at pH 8.0, is inactive below pH 5.0 or above pH 10.5, requires calcium for maximum activity, hydrolyzes fibrinogen, gelatin, and benzoylarginine ethyl ester, and is inhibited by various synthetic and natural proteinase inhibitors. The molecular weight was estimated to be 30,000. Human spermatozoa also possess a proteinase inhibitor that is similar to one of the proteinase inhibitors from human seminal plasma.

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Year:  1972        PMID： 4262344     DOI： 10.1126/science.177.4050.702

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  [Action of different components of the kallikrein kinin-system on sperm motility in vitro (author's transl)].

Authors:  W B Schill; G L Haberland
Journal:  Klin Wochenschr       Date:  1975-01-15

2.  Enhancement of sperm acrosin activity by glycerol-pretreatment - quantitative estimations.

Authors:  W B Schill; H Fritz
Journal:  Arch Dermatol Res       Date:  1976-07-26       Impact factor: 3.017

3.  Fibrinolytic inhibitors in human seminal plasma.

Authors:  P Liedholm; B Astedt
Journal:  Experientia       Date:  1974-10-15

4.  Acrosin activity and acrosome ultrastructure of human spermatozoa after freeze preservation.

Authors:  W B Schill; H H Wolff
Journal:  Naturwissenschaften       Date:  1974-04

5.  Acrosin activity in human spermatozoa: methodological investigations.

Authors:  W B Schill
Journal:  Arch Dermatol Forsch       Date:  1973

Review 6.  Acid extraction of acrosin from human spermatozoa pretreated by different physicochemical methods.

Authors:  W B Schill; M Feifel; H Fritz
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

7.  Studies on ram acrosin. Isolation from spermatozoa, activation by cations and organic solvents, and influence of cations on its reaction with inhibitors.

Authors:  C R Brown; Z Andani; E F Hartree
Journal:  Biochem J       Date:  1975-07       Impact factor: 3.857

8.  [Morphological studies on abnormal human spermatids and spermatozoa (author's transl)].

Authors:  A F Holstein
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1975-07-17

9.  Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006).

Authors:  H Sumi; N Toki
Journal:  Experientia       Date:  1980-09-15

Review 10.  Hepatic and Extrahepatic Sources and Manifestations in Endoplasmic Reticulum Storage Diseases.

Authors:  Francesco Callea; Paola Francalanci; Isabella Giovannoni
Journal:  Int J Mol Sci       Date:  2021-05-28       Impact factor: 5.923
  10 in total

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