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Literature DB >> 4250777

A mechanochemical mechanism for muscle contraction.

Abstract

A mechanism for contraction in skeletal muscle is proposed in which the tension-generating site is located within the core of the thick (myosin) filament, specifically within the trypsin-sensitive hinge region of the myosin rod. The force-developing mechanism is thought to be the transfer of energy from ATP splitting in the globular head of one molecule directly to the hinge region of an adjoining molecule, resulting in a phase transition from crystalline to amorphous within the hinge segment of the second molecule. Binding of MgATP at the actinmyosin interface is considered to be a release mechanism. The model leads to out-of-phase oscillating movement of the cross bridges.

Entities: Chemical Gene

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Year: 1971 PMID： 4250777 PMCID： PMC389017 DOI： 10.1073/pnas.68.3.685

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

31 in total

A mechanochemical mechanism for muscle contraction.

1. THE REGULATION OF MYOFIBRILLAR ACTIVITY BY CALCIUM.

2. ON THE STRUCTURAL ASSEMBLY OF THE POLYPEPTIDE CHAINS OF HEAVY MEROMYOSIN.

3. Elasticity of the fibrous muscle proteins.

4. A model for the myosin molecule.

5. MECHANISM OF CONTRACTION IN THE MUSCLE FIBER-ATP SYSTEM.

6. Role of Crystallization in Polymers and Proteins.

7. The myosin filament. I. Structural organization from antibody staining observed in electron microscopy.

8. Studies on the kinetics of formation and dissociation of the actomyosin complex.

9. Evidence concerning crossbridge attachment during muscle contraction.

10. Composition and mass of peptides released during tryptic and chymotryptic hydrolysis of myosin.

1. Stiffness and tension during and after sudden length changes of glycerinated single insect fibrillar muscle fibres.

2. A Dictyostelium myosin II lacking a proximal 58-kDa portion of the tail is functional in vitro and in vivo.

3. Contraction of myofibrils in the presence of antibodies to myosin subfragment 2.

4. Effect of active pre-shortening on isometric and isotonic performance of single frog muscle fibres.

5. Flexibility of myosin in pyrophosphate and NaCl solutions. An electric birefringence study.

Review 6. The dynamics of actin and myosin association and the crossbridge model of muscle contraction.

7. The molecular origin of birefringence in skeletal muscle. Contribution of myosin subfragment S-1.

8. X-ray diffraction studies on thermally induced tension generation in rigor muscle.

9. A bent monomeric conformation of myosin from smooth muscle.

Review 10. Use of fluorescent techniques to study the in vitro movement of myosins.