| Literature DB >> 424743 |
M S Blank, A E Panerai, H G Friesen.
Abstract
Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.Entities:
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Year: 1979 PMID： 424743 DOI： 10.1126/science.424743
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728