| Literature DB >> 423195 |
M D Aceto, B R Martin, I M Uwaydah, E L May, L S Harris, C Izazola-Conde, W L Dewey, T J Bradshaw, W C Vincek.
Abstract
Optically pure (+)-nicotine has been obtained from (+/-)-nicotine using a combination of d-tartaric acid and di-p-toluoyl-l-tartaric acid. As the di-d-tartrate salt, (+)-nicotine is less potent than (-)-nicotine di-l-tartrate in producing lethality in mice, on blood pressure in anesthetized rats, and in the isolated guinea-pig ileum, indicating substantial stereospecificity for nicotine receptors. Potency ratios are 0.14, 0.06, and 0.019, respectively.Entities:
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Year: 1979 PMID： 423195 DOI： 10.1021/jm00188a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446