| Literature DB >> 423184 |
M E Flaugh, T A Crowell, J A Clemens, B D Sawyer.
Abstract
A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the alpha-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.Entities:
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Year: 1979 PMID： 423184 DOI： 10.1021/jm00187a015
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446